Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective

Past failures in clinical trials have dampened the enthusiasm for studying the HGF receptor MET and postponed the development of MET-targeted drugs for cancer therapy. However, new evidence suggests that, at least in liver cancer, MET is still a promising therapeutic target, and may also be a potent...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Xing, Zhang, Gang, Bai, Xueli, Liang, Tingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781811/
https://www.ncbi.nlm.nih.gov/pubmed/33457099
http://dx.doi.org/10.1080/2162402X.2020.1818438
_version_ 1783631754226040832
author Huang, Xing
Zhang, Gang
Bai, Xueli
Liang, Tingbo
author_facet Huang, Xing
Zhang, Gang
Bai, Xueli
Liang, Tingbo
author_sort Huang, Xing
collection PubMed
description Past failures in clinical trials have dampened the enthusiasm for studying the HGF receptor MET and postponed the development of MET-targeted drugs for cancer therapy. However, new evidence suggests that, at least in liver cancer, MET is still a promising therapeutic target, and may also be a potential target for cancer vaccines. This paper briefly highlights novel research advances in this rapidly-evolving field in the perspective of autophagy, and discusses future directions for further investigation of MET-based cancer therapy and vaccination.
format Online
Article
Text
id pubmed-7781811
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-77818112021-01-14 Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective Huang, Xing Zhang, Gang Bai, Xueli Liang, Tingbo Oncoimmunology Author’s View Past failures in clinical trials have dampened the enthusiasm for studying the HGF receptor MET and postponed the development of MET-targeted drugs for cancer therapy. However, new evidence suggests that, at least in liver cancer, MET is still a promising therapeutic target, and may also be a potential target for cancer vaccines. This paper briefly highlights novel research advances in this rapidly-evolving field in the perspective of autophagy, and discusses future directions for further investigation of MET-based cancer therapy and vaccination. Taylor & Francis 2020-09-13 /pmc/articles/PMC7781811/ /pubmed/33457099 http://dx.doi.org/10.1080/2162402X.2020.1818438 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
Huang, Xing
Zhang, Gang
Bai, Xueli
Liang, Tingbo
Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_full Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_fullStr Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_full_unstemmed Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_short Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_sort reviving the role of met in liver cancer therapy and vaccination: an autophagic perspective
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781811/
https://www.ncbi.nlm.nih.gov/pubmed/33457099
http://dx.doi.org/10.1080/2162402X.2020.1818438
work_keys_str_mv AT huangxing revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective
AT zhanggang revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective
AT baixueli revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective
AT liangtingbo revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective

Ejemplares similares