Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeuti...

Descripción completa

Detalles Bibliográficos
Autores principales: Konda, Prathyusha, Lifshits, Liubov M., Roque, John A., Cole, Houston D., Cameron, Colin G., McFarland, Sherri A., Gujar, Shashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781847/
https://www.ncbi.nlm.nih.gov/pubmed/33457082
http://dx.doi.org/10.1080/2162402X.2020.1863626
Descripción
Sumario:We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

Ejemplares similares