Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeuti...

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Detalles Bibliográficos
Autores principales: Konda, Prathyusha, Lifshits, Liubov M., Roque, John A., Cole, Houston D., Cameron, Colin G., McFarland, Sherri A., Gujar, Shashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781847/
https://www.ncbi.nlm.nih.gov/pubmed/33457082
http://dx.doi.org/10.1080/2162402X.2020.1863626
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author Konda, Prathyusha
Lifshits, Liubov M.
Roque, John A.
Cole, Houston D.
Cameron, Colin G.
McFarland, Sherri A.
Gujar, Shashi
author_facet Konda, Prathyusha
Lifshits, Liubov M.
Roque, John A.
Cole, Houston D.
Cameron, Colin G.
McFarland, Sherri A.
Gujar, Shashi
author_sort Konda, Prathyusha
collection PubMed
description We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.
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spelling pubmed-77818472021-01-14 Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy Konda, Prathyusha Lifshits, Liubov M. Roque, John A. Cole, Houston D. Cameron, Colin G. McFarland, Sherri A. Gujar, Shashi Oncoimmunology Author’s View We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity. Taylor & Francis 2020-12-29 /pmc/articles/PMC7781847/ /pubmed/33457082 http://dx.doi.org/10.1080/2162402X.2020.1863626 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
Konda, Prathyusha
Lifshits, Liubov M.
Roque, John A.
Cole, Houston D.
Cameron, Colin G.
McFarland, Sherri A.
Gujar, Shashi
Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
title Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
title_full Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
title_fullStr Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
title_full_unstemmed Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
title_short Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
title_sort discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781847/
https://www.ncbi.nlm.nih.gov/pubmed/33457082
http://dx.doi.org/10.1080/2162402X.2020.1863626
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