Cargando…

Tumor and germline next generation sequencing in high grade serous cancer: experience from a large population‐based testing program

The aim of this study was to determine the prevalence of somatic and germline pathogenic variants (PVs) in high‐grade serous cancer (HGSC) and to demonstrate the technical feasibility and effectiveness of a large‐scale, population‐based tumor testing program. It involved a retrospective review of ge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Care, Melanie, McCuaig, Jeanna, Clarke, Blaise, Grenier, Sylvie, Kim, Raymond H, Rouzbahman, Marjan, Stickle, Natalie, Bernardini, Marcus, Stockley, Tracy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782089/ https://www.ncbi.nlm.nih.gov/pubmed/33030818 http://dx.doi.org/10.1002/1878-0261.12817

Ejemplares similares

Reflex BRCA1 and BRCA2 tumour genetic testing for high-grade serous ovarian cancer: streamlined for clinicians but what do patients think?
por: McCuaig, Jeanna M., et al.
Publicado: (2022)

Next-Generation Service Delivery: A Scoping Review of Patient Outcomes Associated with Alternative Models of Genetic Counseling and Genetic Testing for Hereditary Cancer
por: McCuaig, Jeanna M., et al.
Publicado: (2018)

Additional germline findings from a tumor profiling program
por: Stjepanovic, Neda, et al.
Publicado: (2018)

Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series
por: Kasherman, Lawrence, et al.
Publicado: (2021)

Incidental findings from cancer next generation sequencing panels
por: Maani, Nika, et al.
Publicado: (2021)

Psychosocial Interventions for Women with a BRCA1 or BRCA2 Mutation: A Scoping Review
por: Boghosian, Talin, et al.
Publicado: (2021)

A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care
por: McCuaig, Jeanna M., et al.
Publicado: (2021)

Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian Cancer
por: Adamson, A.W., et al.
Publicado: (2023)

Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer
por: Adamson, A. W., et al.
Publicado: (2023)

Corrigendum to: Tumor and germline next generation sequencing in high grade serous cancer: experience from a large population‐based testing program
Publicado: (2021)

Molecular Profiling and Clinical Outcome of High-Grade Serous Ovarian Cancer Presenting with Low- versus High-Volume Ascites
por: Feigenberg, Tomer, et al.
Publicado: (2014)

Impact of neoadjuvant chemotherapy on somatic mutation status in high-grade serous ovarian carcinoma
por: Marchocki, Zibi, et al.
Publicado: (2022)

Pelvic congestion syndrome
por: Robertson, Meiri, et al.
Publicado: (2015)

Immunostimulating Commensal Bacteria and Their Potential Use as Therapeutics
por: McCuaig, Bonita, et al.
Publicado: (2023)

NF1 Patients Receiving Breast Cancer Screening: Insights from The Ontario High Risk Breast Screening Program
por: Maani, Nika, et al.
Publicado: (2019)

Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer
por: Eoh, Kyung Jin, et al.
Publicado: (2020)

Germline and tumor BRCA1/2 mutations in Chinese high grade serous ovarian cancer patients
por: Ji, Gang, et al.
Publicado: (2021)

Differential Sensitivity of Germline and Somatic BRCA Variants to PARP Inhibitor in High-Grade Serous Ovarian Cancer
por: Vendrell, Julie A., et al.
Publicado: (2023)

Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas
por: Tone, Alicia A, et al.
Publicado: (2014)

Assessment of Sentinel Lymph Node Biopsy vs Lymphadenectomy for Intermediate- and High-Grade Endometrial Cancer Staging
por: Cusimano, Maria C., et al.
Publicado: (2020)

High-throughput approaches for precision medicine in high-grade serous ovarian cancer
por: Govindarajan, Meinusha, et al.
Publicado: (2020)

Nurse Practitioners in Orthopaedic Surgical Settings: A Review of the Literature
por: Spence, Brittany G., et al.
Publicado: (2019)

The bivalve Thyasira cf. gouldi hosts chemoautotrophic symbiont populations with strain level diversity
por: McCuaig, Bonita, et al.
Publicado: (2017)

Methodological challenges in the comparison of infant fMRI across age groups
por: Cusack, Rhodri, et al.
Publicado: (2017)

Vulvar involvement in epidermolysis bullosa: Case series
por: Dang, Julie, et al.
Publicado: (2021)

Exploring a Complementary Stress Management and Wellbeing Intervention Model for Teachers: Participant Experience
por: Hepburn, Stevie-Jae, et al.
Publicado: (2021)

The Relationship between Mindful Attention Awareness, Perceived Stress and Subjective Wellbeing
por: Hepburn, Stevie-Jae, et al.
Publicado: (2021)

Vitamin D and Calcium Supplement Use and High-Risk Breast Cancer: A Case–Control Study among BRCA1 and BRCA2 Mutation Carriers
por: Guyonnet, Emma, et al.
Publicado: (2023)

Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap
por: McCuaig, Jeanna M, et al.
Publicado: (2018)

Use of Porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: proof of concept in endometrial cancer
por: Philp, Lauren, et al.
Publicado: (2019)

Concurrent Primary Peritoneal Low-Grade Serous Carcinoma and Endometrial High-Grade Serous Carcinoma
por: Lockyer, Megan G., et al.
Publicado: (2015)

Examining the Diagnostic Yield of Tumour Testing and Qualifying Germline Concordance for Hereditary Cancer Variants in Patients with High-Grade Serous Carcinoma
por: Goebel, Emily A., et al.
Publicado: (2022)

Fathers’ Experiences and Perspectives of Breastfeeding: A Scoping Review
por: Sihota, Harvinder, et al.
Publicado: (2019)

Metagenomic analysis suggests broad metabolic potential in extracellular symbionts of the bivalve Thyasira cf. gouldi
por: McCuaig, Bonita, et al.
Publicado: (2020)

A Complementary Intervention to Promote Wellbeing and Stress Management for Early Career Teachers
por: Hepburn, Stevie-Jae, et al.
Publicado: (2021)

Extramedullary hematopoiesis secondary to COVID-19: A first case report in a newborn
por: Caudrelier, Nicolas, et al.
Publicado: (2022)

Unraveling endometriosis-associated ovarian carcinomas using integrative proteomics
por: Leung, Felix, et al.
Publicado: (2018)

Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire
por: Millar, Douglas G., et al.
Publicado: (2023)

Stratified mucin-producing intraepithelial lesion of the cervix: A diagnostic challenge
por: Schwock, Joerg, et al.
Publicado: (2014)

A Case of Postpartum Anogenital Mammary-Like Gland Tumor with Focal Lactational Features: A Nomenclature Issue
por: Thiryayi, Sakinah A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2lli0j8nn4cvtcaitnbo42545e