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Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study

PURPOSE: Colorectal cancer is a well-recognized complication of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s colitis (CC). In this study, we assess the clinico-pathological features and outcomes of patients with colorectal cancer from UC in comparison with CC. METHO...

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Autores principales: Vetter, Leonie E., Merkel, Susanne, Bénard, Alan, Krautz, Christian, Brunner, Maximilian, Mittelstädt, Anke, Schlegel, Nicolas, Wiegering, Armin, Germer, Christoph-Thomas, Weber, Klaus, Grützmann, Robert, Weber, Georg F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782386/
https://www.ncbi.nlm.nih.gov/pubmed/32918621
http://dx.doi.org/10.1007/s00384-020-03726-4
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author Vetter, Leonie E.
Merkel, Susanne
Bénard, Alan
Krautz, Christian
Brunner, Maximilian
Mittelstädt, Anke
Schlegel, Nicolas
Wiegering, Armin
Germer, Christoph-Thomas
Weber, Klaus
Grützmann, Robert
Weber, Georg F.
author_facet Vetter, Leonie E.
Merkel, Susanne
Bénard, Alan
Krautz, Christian
Brunner, Maximilian
Mittelstädt, Anke
Schlegel, Nicolas
Wiegering, Armin
Germer, Christoph-Thomas
Weber, Klaus
Grützmann, Robert
Weber, Georg F.
author_sort Vetter, Leonie E.
collection PubMed
description PURPOSE: Colorectal cancer is a well-recognized complication of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s colitis (CC). In this study, we assess the clinico-pathological features and outcomes of patients with colorectal cancer from UC in comparison with CC. METHODS: Data of all patients with colitis-associated cancer (CAC) who underwent surgery at Erlangen or Würzburg University Clinic between 1995 and 2015 were selected. Clinical, histopathological, and survival data were analyzed retrospectively. RESULTS: Of all 88 patients with CAC, 20 patients had Crohn’s colitis and 68 patients had ulcerative colitis. We observed a young median age at tumor diagnosis (49.5 years UC; 45.5 years CC, p = 0.208) in both diseases and a long median disease duration before CAC (19 years UC; 18 years CC; p = 0.840). Patients with CC suffered more often from rectal cancer (14 (70.0%) in CC; 23 (33.8%) in UC; p = 0.005) and advanced tumor stages (8 (47.0%) pT4 in CC; 14 (25.0%) pT4/ypT4 in UC; p = 0.008). Five-year overall survival rate was 39.3% for CC and 67.1% for UC (p = 0.009 for difference between the groups). Survival did not differ significantly between UC and CC in the multivariate analysis after correction for UICC tumor stage. CONCLUSION: CAC in CC showed advanced tumor stages associated with reduced survival compared with CAC in UC. This may be explained by less intense surveillance in patients with CC leading to delayed cancer diagnosis.
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spelling pubmed-77823862021-01-11 Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study Vetter, Leonie E. Merkel, Susanne Bénard, Alan Krautz, Christian Brunner, Maximilian Mittelstädt, Anke Schlegel, Nicolas Wiegering, Armin Germer, Christoph-Thomas Weber, Klaus Grützmann, Robert Weber, Georg F. Int J Colorectal Dis Original Article PURPOSE: Colorectal cancer is a well-recognized complication of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s colitis (CC). In this study, we assess the clinico-pathological features and outcomes of patients with colorectal cancer from UC in comparison with CC. METHODS: Data of all patients with colitis-associated cancer (CAC) who underwent surgery at Erlangen or Würzburg University Clinic between 1995 and 2015 were selected. Clinical, histopathological, and survival data were analyzed retrospectively. RESULTS: Of all 88 patients with CAC, 20 patients had Crohn’s colitis and 68 patients had ulcerative colitis. We observed a young median age at tumor diagnosis (49.5 years UC; 45.5 years CC, p = 0.208) in both diseases and a long median disease duration before CAC (19 years UC; 18 years CC; p = 0.840). Patients with CC suffered more often from rectal cancer (14 (70.0%) in CC; 23 (33.8%) in UC; p = 0.005) and advanced tumor stages (8 (47.0%) pT4 in CC; 14 (25.0%) pT4/ypT4 in UC; p = 0.008). Five-year overall survival rate was 39.3% for CC and 67.1% for UC (p = 0.009 for difference between the groups). Survival did not differ significantly between UC and CC in the multivariate analysis after correction for UICC tumor stage. CONCLUSION: CAC in CC showed advanced tumor stages associated with reduced survival compared with CAC in UC. This may be explained by less intense surveillance in patients with CC leading to delayed cancer diagnosis. Springer Berlin Heidelberg 2020-09-12 2021 /pmc/articles/PMC7782386/ /pubmed/32918621 http://dx.doi.org/10.1007/s00384-020-03726-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Vetter, Leonie E.
Merkel, Susanne
Bénard, Alan
Krautz, Christian
Brunner, Maximilian
Mittelstädt, Anke
Schlegel, Nicolas
Wiegering, Armin
Germer, Christoph-Thomas
Weber, Klaus
Grützmann, Robert
Weber, Georg F.
Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
title Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
title_full Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
title_fullStr Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
title_full_unstemmed Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
title_short Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
title_sort colorectal cancer in crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782386/
https://www.ncbi.nlm.nih.gov/pubmed/32918621
http://dx.doi.org/10.1007/s00384-020-03726-4
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