Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

Myelin destruction and oligodendrocyte (OL) death consequent to metabolic stress is a feature of CNS disorders across the age spectrum. Using cells derived from surgically resected tissue, we demonstrate that young (<age 5) pediatric-aged sample OLs are more resistant to in-vitro metabolic injury...

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Detalles Bibliográficos
Autores principales: Fernandes, Milton Guilherme Forestieri, Luo, Julia Xiao Xuan, Cui, Qiao-Ling, Perlman, Kelly, Pernin, Florian, Yaqubi, Moein, Hall, Jeffery A., Dudley, Roy, Srour, Myriam, Couturier, Charles P., Petrecca, Kevin, Larochelle, Catherine, Healy, Luke M., Stratton, Jo Anne, Kennedy, Timothy E., Antel, Jack P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782481/
https://www.ncbi.nlm.nih.gov/pubmed/33398046
http://dx.doi.org/10.1038/s42003-020-01557-1

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