Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activit...

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Detalles Bibliográficos
Autores principales: Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K., Chothani, Sonia P., Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole S. J., Shekeran, Shamini G., Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M., Schafer, Sebastian, Cook, Stuart A., Widjaja, Anissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782504/
https://www.ncbi.nlm.nih.gov/pubmed/33397952
http://dx.doi.org/10.1038/s41467-020-20303-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782504/
https://www.ncbi.nlm.nih.gov/pubmed/33397952
http://dx.doi.org/10.1038/s41467-020-20303-z

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