Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin

The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective articl...

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Autores principales: Gaire, Janak, Varholick, Justin A., Rana, Sabhya, Sunshine, Michael D., Doré, Sylvain, Barbazuk, W. Brad, Fuller, David D., Maden, Malcolm, Simmons, Chelsey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782534/
https://www.ncbi.nlm.nih.gov/pubmed/33397999
http://dx.doi.org/10.1038/s41536-020-00111-1
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author Gaire, Janak
Varholick, Justin A.
Rana, Sabhya
Sunshine, Michael D.
Doré, Sylvain
Barbazuk, W. Brad
Fuller, David D.
Maden, Malcolm
Simmons, Chelsey S.
author_facet Gaire, Janak
Varholick, Justin A.
Rana, Sabhya
Sunshine, Michael D.
Doré, Sylvain
Barbazuk, W. Brad
Fuller, David D.
Maden, Malcolm
Simmons, Chelsey S.
author_sort Gaire, Janak
collection PubMed
description The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective article, we discuss published findings from a variety of tissues to highlight how this emerging research organism could shed light on numerous clinically relevant human diseases. We also discuss the challenges of working with this emerging research organism and suggest strategies for future Acomys-inspired research.
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spelling pubmed-77825342021-01-11 Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin Gaire, Janak Varholick, Justin A. Rana, Sabhya Sunshine, Michael D. Doré, Sylvain Barbazuk, W. Brad Fuller, David D. Maden, Malcolm Simmons, Chelsey S. NPJ Regen Med Perspective The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective article, we discuss published findings from a variety of tissues to highlight how this emerging research organism could shed light on numerous clinically relevant human diseases. We also discuss the challenges of working with this emerging research organism and suggest strategies for future Acomys-inspired research. Nature Publishing Group UK 2021-01-04 /pmc/articles/PMC7782534/ /pubmed/33397999 http://dx.doi.org/10.1038/s41536-020-00111-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Gaire, Janak
Varholick, Justin A.
Rana, Sabhya
Sunshine, Michael D.
Doré, Sylvain
Barbazuk, W. Brad
Fuller, David D.
Maden, Malcolm
Simmons, Chelsey S.
Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
title Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
title_full Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
title_fullStr Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
title_full_unstemmed Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
title_short Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
title_sort spiny mouse (acomys): an emerging research organism for regenerative medicine with applications beyond the skin
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782534/
https://www.ncbi.nlm.nih.gov/pubmed/33397999
http://dx.doi.org/10.1038/s41536-020-00111-1
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