miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Diabetic kidney disease (DKD) is a major complication of diabetes. Expression of members of the microRNA (miRNA) miR-379 cluster is increased in DKD. miR-379, the most upstream 5′-miRNA in the cluster, functions in endoplasmic reticulum (ER) stress by targeting EDEM3. However, the in vivo functions...

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Detalles Bibliográficos
Autores principales: Kato, Mitsuo, Abdollahi, Maryam, Tunduguru, Ragadeepthi, Tsark, Walter, Chen, Zhuo, Wu, Xiwei, Wang, Jinhui, Chen, Zhen Bouman, Lin, Feng-Mao, Lanting, Linda, Wang, Mei, Huss, Janice, Fueger, Patrick T, Chan, David, Natarajan, Rama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782535/
https://www.ncbi.nlm.nih.gov/pubmed/33398021
http://dx.doi.org/10.1038/s42003-020-01516-w

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