A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates

We present a non-human primate mycobacterial growth inhibition assay (MGIA) using in vitro blood or cell co-culture with the aim of refining and expediting early tuberculosis vaccine testing. We have taken steps to optimise the assay using cryopreserved peripheral blood mononuclear cells, transfer i...

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Detalles Bibliográficos
Autores principales: Tanner, Rachel, White, Andrew D., Boot, Charelle, Sombroek, Claudia C., O’Shea, Matthew K., Wright, Daniel, Hoogkamer, Emily, Bitencourt, Julia, Harris, Stephanie A., Sarfas, Charlotte, Wittenberg, Rachel, Satti, Iman, Fletcher, Helen A., Verreck, Frank A. W., Sharpe, Sally A., McShane, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782578/
https://www.ncbi.nlm.nih.gov/pubmed/33397986
http://dx.doi.org/10.1038/s41541-020-00263-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782578/
https://www.ncbi.nlm.nih.gov/pubmed/33397986
http://dx.doi.org/10.1038/s41541-020-00263-7

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