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Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/− binimetinib or alpelisib

BACKGROUND: Treatment strategies inhibiting BRAF in combination with EGFR have been developed in patients with BRAF(V600E) mutant metastatic colorectal cancer, but intrinsic and secondary resistance remains a challenge. We aimed to investigate which genetic alterations cause intrinsic non-response a...

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Detalles Bibliográficos
Autores principales:	Huijberts, Sanne C. F. A., Boelens, Mirjam C., Bernards, Rene, Opdam, Frans L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782586/ https://www.ncbi.nlm.nih.gov/pubmed/33204026 http://dx.doi.org/10.1038/s41416-020-01147-2

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