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Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients

Conventional CT scanners use energy-integrating detectors (EIDs). Photon-counting detector (PCD) computed tomography (CT) utilizes a CT detector technology based on smaller detector pixels capable of counting single photons and in addition discriminating their energy. Goal of this study was to explo...

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Autores principales: Wehrse, E., Sawall, S., Klein, L., Glemser, P., Delorme, S., Schlemmer, H.-P., Kachelrieß, M., Uhrig, M., Ziener, C. H., Rotkopf, L. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782694/
https://www.ncbi.nlm.nih.gov/pubmed/33398008
http://dx.doi.org/10.1038/s41523-020-00207-3
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author Wehrse, E.
Sawall, S.
Klein, L.
Glemser, P.
Delorme, S.
Schlemmer, H.-P.
Kachelrieß, M.
Uhrig, M.
Ziener, C. H.
Rotkopf, L. T.
author_facet Wehrse, E.
Sawall, S.
Klein, L.
Glemser, P.
Delorme, S.
Schlemmer, H.-P.
Kachelrieß, M.
Uhrig, M.
Ziener, C. H.
Rotkopf, L. T.
author_sort Wehrse, E.
collection PubMed
description Conventional CT scanners use energy-integrating detectors (EIDs). Photon-counting detector (PCD) computed tomography (CT) utilizes a CT detector technology based on smaller detector pixels capable of counting single photons and in addition discriminating their energy. Goal of this study was to explore the potential of higher spatial resolution for imaging of bone metastases. Four female patients with histologically confirmed breast cancer and bone metastases were included between July and October 2019. All patients underwent conventional EID CT scans followed by a high resolution non-contrast experimental PCD CT scan. Ultra-high resolution (UHR) reconstruction kernels were used to reconstruct axial slices with voxel sizes of 0.3 mm × 0.3 mm (inplane) × 1 mm (z-direction). Four radiologists blinded for patient identity assessed the images and compared the quality to conventional CT using a qualitative Likert scale. In this case series, we present images of bone metastases in breast cancer patients using an experimental PCD CT scanner and ultra-high-resolution kernels. A tendency to both a smaller inter-reader variability in the structural assessment of lesion sizes and in the readers’ opinion to an improved visualization of lesion margins and content was observed. In conclusion, while further studies are warranted, PCD CT has a high potential for therapy monitoring in breast cancer.
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spelling pubmed-77826942021-01-11 Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients Wehrse, E. Sawall, S. Klein, L. Glemser, P. Delorme, S. Schlemmer, H.-P. Kachelrieß, M. Uhrig, M. Ziener, C. H. Rotkopf, L. T. NPJ Breast Cancer Case Report Conventional CT scanners use energy-integrating detectors (EIDs). Photon-counting detector (PCD) computed tomography (CT) utilizes a CT detector technology based on smaller detector pixels capable of counting single photons and in addition discriminating their energy. Goal of this study was to explore the potential of higher spatial resolution for imaging of bone metastases. Four female patients with histologically confirmed breast cancer and bone metastases were included between July and October 2019. All patients underwent conventional EID CT scans followed by a high resolution non-contrast experimental PCD CT scan. Ultra-high resolution (UHR) reconstruction kernels were used to reconstruct axial slices with voxel sizes of 0.3 mm × 0.3 mm (inplane) × 1 mm (z-direction). Four radiologists blinded for patient identity assessed the images and compared the quality to conventional CT using a qualitative Likert scale. In this case series, we present images of bone metastases in breast cancer patients using an experimental PCD CT scanner and ultra-high-resolution kernels. A tendency to both a smaller inter-reader variability in the structural assessment of lesion sizes and in the readers’ opinion to an improved visualization of lesion margins and content was observed. In conclusion, while further studies are warranted, PCD CT has a high potential for therapy monitoring in breast cancer. Nature Publishing Group UK 2021-01-04 /pmc/articles/PMC7782694/ /pubmed/33398008 http://dx.doi.org/10.1038/s41523-020-00207-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Wehrse, E.
Sawall, S.
Klein, L.
Glemser, P.
Delorme, S.
Schlemmer, H.-P.
Kachelrieß, M.
Uhrig, M.
Ziener, C. H.
Rotkopf, L. T.
Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients
title Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients
title_full Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients
title_fullStr Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients
title_full_unstemmed Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients
title_short Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients
title_sort potential of ultra-high-resolution photon-counting ct of bone metastases: initial experiences in breast cancer patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782694/
https://www.ncbi.nlm.nih.gov/pubmed/33398008
http://dx.doi.org/10.1038/s41523-020-00207-3
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