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Genetic and pharmacological inhibition of the nuclear receptor RORα regulates T(H)17 driven inflammatory disorders

Full development of IL-17 producing CD4(+) T helper cells (T(H)17 cells) requires the transcriptional activity of both orphan nuclear receptors RORα and RORγt. However, RORα is considered functionally redundant to RORγt; therefore, the function and therapeutic value of RORα in T(H)17 cells is unclea...

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Detalles Bibliográficos
Autores principales:	Wang, Ran, Campbell, Sean, Amir, Mohammed, Mosure, Sarah A., Bassette, Molly A., Eliason, Amber, Sundrud, Mark S., Kamenecka, Theodore M., Solt, Laura A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782731/ https://www.ncbi.nlm.nih.gov/pubmed/33397953 http://dx.doi.org/10.1038/s41467-020-20385-9

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