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Roles of mitochondria in the hallmarks of metastasis
Although mitochondrial contributions to cancer have been recognised for approximately a century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome (nDNA), nuclear genetics has represented a focal point in cancer biology, often at the expense of mtDNA and mitochondria....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782743/ https://www.ncbi.nlm.nih.gov/pubmed/33144695 http://dx.doi.org/10.1038/s41416-020-01125-8 |
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author | Scheid, Adam D. Beadnell, Thomas C. Welch, Danny R. |
author_facet | Scheid, Adam D. Beadnell, Thomas C. Welch, Danny R. |
author_sort | Scheid, Adam D. |
collection | PubMed |
description | Although mitochondrial contributions to cancer have been recognised for approximately a century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome (nDNA), nuclear genetics has represented a focal point in cancer biology, often at the expense of mtDNA and mitochondria. However, genomic sequencing and advances in in vivo models underscore the importance of mtDNA and mitochondria in cancer and metastasis. In this review, we explore the roles of mitochondria in the four defined ‘hallmarks of metastasis’: motility and invasion, microenvironment modulation, plasticity and colonisation. Biochemical processes within the mitochondria of both cancer cells and the stromal cells with which they interact are critical for each metastatic hallmark. We unravel complex dynamics in mitochondrial contributions to cancer, which are context-dependent and capable of either promoting metastasis or being leveraged to prevent it at various points of the metastatic cascade. Ultimately, mitochondrial contributions to cancer and metastasis are rooted in the capacity of these organelles to tune metabolic and genetic responses to dynamic microenvironmental cues. |
format | Online Article Text |
id | pubmed-7782743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77827432021-11-04 Roles of mitochondria in the hallmarks of metastasis Scheid, Adam D. Beadnell, Thomas C. Welch, Danny R. Br J Cancer Review Article Although mitochondrial contributions to cancer have been recognised for approximately a century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome (nDNA), nuclear genetics has represented a focal point in cancer biology, often at the expense of mtDNA and mitochondria. However, genomic sequencing and advances in in vivo models underscore the importance of mtDNA and mitochondria in cancer and metastasis. In this review, we explore the roles of mitochondria in the four defined ‘hallmarks of metastasis’: motility and invasion, microenvironment modulation, plasticity and colonisation. Biochemical processes within the mitochondria of both cancer cells and the stromal cells with which they interact are critical for each metastatic hallmark. We unravel complex dynamics in mitochondrial contributions to cancer, which are context-dependent and capable of either promoting metastasis or being leveraged to prevent it at various points of the metastatic cascade. Ultimately, mitochondrial contributions to cancer and metastasis are rooted in the capacity of these organelles to tune metabolic and genetic responses to dynamic microenvironmental cues. Nature Publishing Group UK 2020-11-04 2021-01-05 /pmc/articles/PMC7782743/ /pubmed/33144695 http://dx.doi.org/10.1038/s41416-020-01125-8 Text en © The Author(s), under exclusive licence to Cancer Research UK 2020 https://creativecommons.org/licenses/by/4.0/ Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0). |
spellingShingle | Review Article Scheid, Adam D. Beadnell, Thomas C. Welch, Danny R. Roles of mitochondria in the hallmarks of metastasis |
title | Roles of mitochondria in the hallmarks of metastasis |
title_full | Roles of mitochondria in the hallmarks of metastasis |
title_fullStr | Roles of mitochondria in the hallmarks of metastasis |
title_full_unstemmed | Roles of mitochondria in the hallmarks of metastasis |
title_short | Roles of mitochondria in the hallmarks of metastasis |
title_sort | roles of mitochondria in the hallmarks of metastasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782743/ https://www.ncbi.nlm.nih.gov/pubmed/33144695 http://dx.doi.org/10.1038/s41416-020-01125-8 |
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