DNA–protein crosslink proteases in genome stability

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases,...

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Detalles Bibliográficos
Autores principales: Ruggiano, Annamaria, Ramadan, Kristijan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782752/
https://www.ncbi.nlm.nih.gov/pubmed/33398053
http://dx.doi.org/10.1038/s42003-020-01539-3
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author Ruggiano, Annamaria
Ramadan, Kristijan
author_facet Ruggiano, Annamaria
Ramadan, Kristijan
author_sort Ruggiano, Annamaria
collection PubMed
description Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases, which digest the protein component of a DPC. Interestingly, DPC proteases also play a role in proteolysis beside DPC repair, such as in degrading excess histones during DNA replication or controlling DNA replication checkpoints. Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer therapy.
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spelling pubmed-77827522021-01-11 DNA–protein crosslink proteases in genome stability Ruggiano, Annamaria Ramadan, Kristijan Commun Biol Review Article Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases, which digest the protein component of a DPC. Interestingly, DPC proteases also play a role in proteolysis beside DPC repair, such as in degrading excess histones during DNA replication or controlling DNA replication checkpoints. Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer therapy. Nature Publishing Group UK 2021-01-04 /pmc/articles/PMC7782752/ /pubmed/33398053 http://dx.doi.org/10.1038/s42003-020-01539-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Ruggiano, Annamaria
Ramadan, Kristijan
DNA–protein crosslink proteases in genome stability
title DNA–protein crosslink proteases in genome stability
title_full DNA–protein crosslink proteases in genome stability
title_fullStr DNA–protein crosslink proteases in genome stability
title_full_unstemmed DNA–protein crosslink proteases in genome stability
title_short DNA–protein crosslink proteases in genome stability
title_sort dna–protein crosslink proteases in genome stability
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782752/
https://www.ncbi.nlm.nih.gov/pubmed/33398053
http://dx.doi.org/10.1038/s42003-020-01539-3
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