MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies

A single intradermal vaccination with MTBVAC given to adult rhesus macaques was well tolerated and conferred a significant improvement in outcome following aerosol exposure to M. tuberculosis compared to that provided by a single BCG vaccination. Vaccination with MTBVAC resulted in a significant red...

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Detalles Bibliográficos
Autores principales: White, Andrew D., Sibley, Laura, Sarfas, Charlotte, Morrison, Alexandra, Gullick, Jennie, Clark, Simon, Gleeson, Fergus, McIntyre, Anthony, Arlehamn, Cecilia Lindestam, Sette, Alessandro, Salguero, Francisco J., Rayner, Emma, Rodriguez, Esteban, Puentes, Eugenia, Laddy, Dominick, Williams, Ann, Dennis, Mike, Martin, Carlos, Sharpe, Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782851/
https://www.ncbi.nlm.nih.gov/pubmed/33397991
http://dx.doi.org/10.1038/s41541-020-00262-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782851/
https://www.ncbi.nlm.nih.gov/pubmed/33397991
http://dx.doi.org/10.1038/s41541-020-00262-8

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