Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens

A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS...

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Detalles Bibliográficos
Autores principales: Favara, D. M., Ceron-Gutierrez, M. L., Carnell, G. W., Heeney, J. L., Corrie, P., Doffinger, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782901/
https://www.ncbi.nlm.nih.gov/pubmed/33258732
http://dx.doi.org/10.1080/22221751.2020.1858699
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author Favara, D. M.
Ceron-Gutierrez, M. L.
Carnell, G. W.
Heeney, J. L.
Corrie, P.
Doffinger, R.
author_facet Favara, D. M.
Ceron-Gutierrez, M. L.
Carnell, G. W.
Heeney, J. L.
Corrie, P.
Doffinger, R.
author_sort Favara, D. M.
collection PubMed
description A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk pasteurization did not diminish SARS-CoV-2 antibody titres but it reduced its neutralizing capacity, while serum heat inactivation had no negative effect on SARS-CoV-2 serum antibody levels and neutralizing capacity. Current data on SARS-CoV-2 and breastmilk are reviewed.
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spelling pubmed-77829012021-01-14 Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens Favara, D. M. Ceron-Gutierrez, M. L. Carnell, G. W. Heeney, J. L. Corrie, P. Doffinger, R. Emerg Microbes Infect Letter A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk pasteurization did not diminish SARS-CoV-2 antibody titres but it reduced its neutralizing capacity, while serum heat inactivation had no negative effect on SARS-CoV-2 serum antibody levels and neutralizing capacity. Current data on SARS-CoV-2 and breastmilk are reviewed. Taylor & Francis 2020-12-27 /pmc/articles/PMC7782901/ /pubmed/33258732 http://dx.doi.org/10.1080/22221751.2020.1858699 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Favara, D. M.
Ceron-Gutierrez, M. L.
Carnell, G. W.
Heeney, J. L.
Corrie, P.
Doffinger, R.
Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
title Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
title_full Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
title_fullStr Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
title_full_unstemmed Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
title_short Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
title_sort detection of breastmilk antibodies targeting sars-cov-2 nucleocapsid, spike and receptor-binding-domain antigens
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782901/
https://www.ncbi.nlm.nih.gov/pubmed/33258732
http://dx.doi.org/10.1080/22221751.2020.1858699
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