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Development of spray-dried amorphous solid dispersions of tadalafil using glycyrrhizin for enhanced dissolution and aphrodisiac activity in male rats

Tadalafil (TDL) is a phosphodiesterase-5 inhibitor (PDE5I), indicated for erectile dysfunction (ED). However, TDL exhibits poor aqueous solubility and dissolution rate, which may limit its application. This study aims to prepare amorphous solid dispersion (ASD) by spray-drying, using glycyrrhizin-a...

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Detalles Bibliográficos
Autores principales:	Muqtader Ahmed, Mohammed, Fatima, Farhat, Abul Kalam, Mohd, Alshamsan, Aws, Soliman, Gamal A., Shaikh, Abdul Azim, Alshahrani, Saad M, Aldawsari, Mohammed F., Bhatia, Saurabh, Khalid Anwer, Md.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783211/ https://www.ncbi.nlm.nih.gov/pubmed/33424269 http://dx.doi.org/10.1016/j.jsps.2020.11.007

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