Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability

Simvastatin (SV) repurposing has emerged as an alternative approach for the treatment of cancer. In this study, SV chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate (SVCSChSNPs) were developed in order to maximize SV therapeutic efficiency. The hepatic targeting was...

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Detalles Bibliográficos
Autores principales: Faris, Tarek M., Harisa, Gamaleldin I., Alanazi, Fars K., Samy, Ahmed M., Nasr, Fahd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783227/
https://www.ncbi.nlm.nih.gov/pubmed/33424274
http://dx.doi.org/10.1016/j.jsps.2020.11.012

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