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Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19

In the absence of a consensus protocol to slow down the spread of SARS-CoV-2, policymakers need real-time indicators to support decisions in public health matters. The Effective Reproduction Number (R(t)) represents the number of secondary infections generated per each case and can be dramatically m...

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Autores principales: Contreras, Sebastián, Villavicencio, H. Andrés, Medina-Ortiz, David, Saavedra, Claudia P., Olivera-Nappa, Álvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783316/
https://www.ncbi.nlm.nih.gov/pubmed/33415091
http://dx.doi.org/10.3389/fpubh.2020.556689
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author Contreras, Sebastián
Villavicencio, H. Andrés
Medina-Ortiz, David
Saavedra, Claudia P.
Olivera-Nappa, Álvaro
author_facet Contreras, Sebastián
Villavicencio, H. Andrés
Medina-Ortiz, David
Saavedra, Claudia P.
Olivera-Nappa, Álvaro
author_sort Contreras, Sebastián
collection PubMed
description In the absence of a consensus protocol to slow down the spread of SARS-CoV-2, policymakers need real-time indicators to support decisions in public health matters. The Effective Reproduction Number (R(t)) represents the number of secondary infections generated per each case and can be dramatically modified by applying effective interventions. However, current methodologies to calculate R(t) from data remain somewhat cumbersome, thus raising a barrier between its timely calculation and application by policymakers. In this work, we provide a simple mathematical formulation for obtaining the effective reproduction number in real-time using only and directly daily official case reports, obtained by modifying the equations describing the viral spread. We numerically explore the accuracy and limitations of the proposed methodology, which was demonstrated to provide accurate, timely, and intuitive results. We illustrate the use of our methodology to study the evolution of the pandemic in different iconic countries, and to assess the efficacy and promptness of different public health interventions.
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spelling pubmed-77833162021-01-06 Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19 Contreras, Sebastián Villavicencio, H. Andrés Medina-Ortiz, David Saavedra, Claudia P. Olivera-Nappa, Álvaro Front Public Health Public Health In the absence of a consensus protocol to slow down the spread of SARS-CoV-2, policymakers need real-time indicators to support decisions in public health matters. The Effective Reproduction Number (R(t)) represents the number of secondary infections generated per each case and can be dramatically modified by applying effective interventions. However, current methodologies to calculate R(t) from data remain somewhat cumbersome, thus raising a barrier between its timely calculation and application by policymakers. In this work, we provide a simple mathematical formulation for obtaining the effective reproduction number in real-time using only and directly daily official case reports, obtained by modifying the equations describing the viral spread. We numerically explore the accuracy and limitations of the proposed methodology, which was demonstrated to provide accurate, timely, and intuitive results. We illustrate the use of our methodology to study the evolution of the pandemic in different iconic countries, and to assess the efficacy and promptness of different public health interventions. Frontiers Media S.A. 2020-12-22 /pmc/articles/PMC7783316/ /pubmed/33415091 http://dx.doi.org/10.3389/fpubh.2020.556689 Text en Copyright © 2020 Contreras, Villavicencio, Medina-Ortiz, Saavedra and Olivera-Nappa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Contreras, Sebastián
Villavicencio, H. Andrés
Medina-Ortiz, David
Saavedra, Claudia P.
Olivera-Nappa, Álvaro
Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19
title Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19
title_full Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19
title_fullStr Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19
title_full_unstemmed Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19
title_short Real-Time Estimation of R(t) for Supporting Public-Health Policies Against COVID-19
title_sort real-time estimation of r(t) for supporting public-health policies against covid-19
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783316/
https://www.ncbi.nlm.nih.gov/pubmed/33415091
http://dx.doi.org/10.3389/fpubh.2020.556689
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