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Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection

The outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitiv...

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Autores principales: Peng, Yusi, Lin, Chenglong, Long, Li, Masaki, Tanemura, Tang, Mao, Yang, Lili, Liu, Jianjun, Huang, Zhengren, Li, Zhiyuan, Luo, Xiaoying, Lombardi, John R., Yang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783703/
https://www.ncbi.nlm.nih.gov/pubmed/33425476
http://dx.doi.org/10.1007/s40820-020-00565-4
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author Peng, Yusi
Lin, Chenglong
Long, Li
Masaki, Tanemura
Tang, Mao
Yang, Lili
Liu, Jianjun
Huang, Zhengren
Li, Zhiyuan
Luo, Xiaoying
Lombardi, John R.
Yang, Yong
author_facet Peng, Yusi
Lin, Chenglong
Long, Li
Masaki, Tanemura
Tang, Mao
Yang, Lili
Liu, Jianjun
Huang, Zhengren
Li, Zhiyuan
Luo, Xiaoying
Lombardi, John R.
Yang, Yong
author_sort Peng, Yusi
collection PubMed
description The outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity. Therefore, it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity. Herein we report, for the first time, Nb(2)C and Ta(2)C MXenes exhibit a remarkable SERS enhancement, which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement. Their SERS sensitivity is optimized to 3.0 × 10(6) and 1.4 × 10(6) under the optimal resonance excitation wavelength of 532 nm. Additionally, remarkable SERS sensitivity endows Ta(2)C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein. Moreover, its detection limit is as low as 5 × 10(−9) M, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-020-00565-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-77837032021-01-05 Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection Peng, Yusi Lin, Chenglong Long, Li Masaki, Tanemura Tang, Mao Yang, Lili Liu, Jianjun Huang, Zhengren Li, Zhiyuan Luo, Xiaoying Lombardi, John R. Yang, Yong Nanomicro Lett Article The outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity. Therefore, it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity. Herein we report, for the first time, Nb(2)C and Ta(2)C MXenes exhibit a remarkable SERS enhancement, which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement. Their SERS sensitivity is optimized to 3.0 × 10(6) and 1.4 × 10(6) under the optimal resonance excitation wavelength of 532 nm. Additionally, remarkable SERS sensitivity endows Ta(2)C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein. Moreover, its detection limit is as low as 5 × 10(−9) M, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-020-00565-4) contains supplementary material, which is available to authorized users. Springer Nature Singapore 2021-01-05 /pmc/articles/PMC7783703/ /pubmed/33425476 http://dx.doi.org/10.1007/s40820-020-00565-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Peng, Yusi
Lin, Chenglong
Long, Li
Masaki, Tanemura
Tang, Mao
Yang, Lili
Liu, Jianjun
Huang, Zhengren
Li, Zhiyuan
Luo, Xiaoying
Lombardi, John R.
Yang, Yong
Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection
title Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection
title_full Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection
title_fullStr Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection
title_full_unstemmed Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection
title_short Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection
title_sort charge-transfer resonance and electromagnetic enhancement synergistically enabling mxenes with excellent sers sensitivity for sars-cov-2 s protein detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783703/
https://www.ncbi.nlm.nih.gov/pubmed/33425476
http://dx.doi.org/10.1007/s40820-020-00565-4
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