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Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players

Muscles of candidates work at various grades of intensity during handball exercises according to the pace of exercise. The movement pattern involves large number of contractions, feints, dodges and numerous changes in movements, all of which are highly responsible for changes in trainer's organ...

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Autores principales: Amin, Mohamed N., El-Mowafy, Mohammed, Mobark, Ali, Abass, Naglaa, Elgaml, Abdelaziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783837/
https://www.ncbi.nlm.nih.gov/pubmed/33424360
http://dx.doi.org/10.1016/j.sjbs.2020.10.065
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author Amin, Mohamed N.
El-Mowafy, Mohammed
Mobark, Ali
Abass, Naglaa
Elgaml, Abdelaziz
author_facet Amin, Mohamed N.
El-Mowafy, Mohammed
Mobark, Ali
Abass, Naglaa
Elgaml, Abdelaziz
author_sort Amin, Mohamed N.
collection PubMed
description Muscles of candidates work at various grades of intensity during handball exercises according to the pace of exercise. The movement pattern involves large number of contractions, feints, dodges and numerous changes in movements, all of which are highly responsible for changes in trainer's organs, including the immune system. In this study, inflammatory mediators involving interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in serum of 18 Egyptian male handball players, selected from Tanta club handball under 21 year’s old team, were analyzed. The analysis was established on samples collected just before and immediately after intermediate reasonable exercise via enzyme linked immunosorbent assay (ELISA). Moreover, white blood cells (WBCs) count and other hematological markers including hemoglobin %, hematocrit value, and platelet count were assessed. Our results demonstrated a significant decrease in the levels of IL-6 and TNF-α after exercise compared to those before exercise. This was coupled with an increase in WBCs and platelets count. It is also noteworthy that there was a significant positive correlation between serum levels of IL-6 and TNF-α in the study subjects coupled with a significant negative correlation between IL-6 and WBCs after the exercise. Therefore, it is concluded that intermediate reasonable exercises result in decreased levels of IL-6 and TNF-α, which result in decreasing of the inflammation and help in healing and rapid recovery of muscles of the candidates.
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spelling pubmed-77838372021-01-08 Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players Amin, Mohamed N. El-Mowafy, Mohammed Mobark, Ali Abass, Naglaa Elgaml, Abdelaziz Saudi J Biol Sci Original Article Muscles of candidates work at various grades of intensity during handball exercises according to the pace of exercise. The movement pattern involves large number of contractions, feints, dodges and numerous changes in movements, all of which are highly responsible for changes in trainer's organs, including the immune system. In this study, inflammatory mediators involving interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in serum of 18 Egyptian male handball players, selected from Tanta club handball under 21 year’s old team, were analyzed. The analysis was established on samples collected just before and immediately after intermediate reasonable exercise via enzyme linked immunosorbent assay (ELISA). Moreover, white blood cells (WBCs) count and other hematological markers including hemoglobin %, hematocrit value, and platelet count were assessed. Our results demonstrated a significant decrease in the levels of IL-6 and TNF-α after exercise compared to those before exercise. This was coupled with an increase in WBCs and platelets count. It is also noteworthy that there was a significant positive correlation between serum levels of IL-6 and TNF-α in the study subjects coupled with a significant negative correlation between IL-6 and WBCs after the exercise. Therefore, it is concluded that intermediate reasonable exercises result in decreased levels of IL-6 and TNF-α, which result in decreasing of the inflammation and help in healing and rapid recovery of muscles of the candidates. Elsevier 2021-01 2020-11-05 /pmc/articles/PMC7783837/ /pubmed/33424360 http://dx.doi.org/10.1016/j.sjbs.2020.10.065 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Amin, Mohamed N.
El-Mowafy, Mohammed
Mobark, Ali
Abass, Naglaa
Elgaml, Abdelaziz
Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players
title Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players
title_full Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players
title_fullStr Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players
title_full_unstemmed Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players
title_short Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players
title_sort exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in egyptian handball players
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783837/
https://www.ncbi.nlm.nih.gov/pubmed/33424360
http://dx.doi.org/10.1016/j.sjbs.2020.10.065
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