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Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players
Muscles of candidates work at various grades of intensity during handball exercises according to the pace of exercise. The movement pattern involves large number of contractions, feints, dodges and numerous changes in movements, all of which are highly responsible for changes in trainer's organ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783837/ https://www.ncbi.nlm.nih.gov/pubmed/33424360 http://dx.doi.org/10.1016/j.sjbs.2020.10.065 |
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author | Amin, Mohamed N. El-Mowafy, Mohammed Mobark, Ali Abass, Naglaa Elgaml, Abdelaziz |
author_facet | Amin, Mohamed N. El-Mowafy, Mohammed Mobark, Ali Abass, Naglaa Elgaml, Abdelaziz |
author_sort | Amin, Mohamed N. |
collection | PubMed |
description | Muscles of candidates work at various grades of intensity during handball exercises according to the pace of exercise. The movement pattern involves large number of contractions, feints, dodges and numerous changes in movements, all of which are highly responsible for changes in trainer's organs, including the immune system. In this study, inflammatory mediators involving interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in serum of 18 Egyptian male handball players, selected from Tanta club handball under 21 year’s old team, were analyzed. The analysis was established on samples collected just before and immediately after intermediate reasonable exercise via enzyme linked immunosorbent assay (ELISA). Moreover, white blood cells (WBCs) count and other hematological markers including hemoglobin %, hematocrit value, and platelet count were assessed. Our results demonstrated a significant decrease in the levels of IL-6 and TNF-α after exercise compared to those before exercise. This was coupled with an increase in WBCs and platelets count. It is also noteworthy that there was a significant positive correlation between serum levels of IL-6 and TNF-α in the study subjects coupled with a significant negative correlation between IL-6 and WBCs after the exercise. Therefore, it is concluded that intermediate reasonable exercises result in decreased levels of IL-6 and TNF-α, which result in decreasing of the inflammation and help in healing and rapid recovery of muscles of the candidates. |
format | Online Article Text |
id | pubmed-7783837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77838372021-01-08 Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players Amin, Mohamed N. El-Mowafy, Mohammed Mobark, Ali Abass, Naglaa Elgaml, Abdelaziz Saudi J Biol Sci Original Article Muscles of candidates work at various grades of intensity during handball exercises according to the pace of exercise. The movement pattern involves large number of contractions, feints, dodges and numerous changes in movements, all of which are highly responsible for changes in trainer's organs, including the immune system. In this study, inflammatory mediators involving interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in serum of 18 Egyptian male handball players, selected from Tanta club handball under 21 year’s old team, were analyzed. The analysis was established on samples collected just before and immediately after intermediate reasonable exercise via enzyme linked immunosorbent assay (ELISA). Moreover, white blood cells (WBCs) count and other hematological markers including hemoglobin %, hematocrit value, and platelet count were assessed. Our results demonstrated a significant decrease in the levels of IL-6 and TNF-α after exercise compared to those before exercise. This was coupled with an increase in WBCs and platelets count. It is also noteworthy that there was a significant positive correlation between serum levels of IL-6 and TNF-α in the study subjects coupled with a significant negative correlation between IL-6 and WBCs after the exercise. Therefore, it is concluded that intermediate reasonable exercises result in decreased levels of IL-6 and TNF-α, which result in decreasing of the inflammation and help in healing and rapid recovery of muscles of the candidates. Elsevier 2021-01 2020-11-05 /pmc/articles/PMC7783837/ /pubmed/33424360 http://dx.doi.org/10.1016/j.sjbs.2020.10.065 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Amin, Mohamed N. El-Mowafy, Mohammed Mobark, Ali Abass, Naglaa Elgaml, Abdelaziz Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players |
title | Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players |
title_full | Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players |
title_fullStr | Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players |
title_full_unstemmed | Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players |
title_short | Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players |
title_sort | exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in egyptian handball players |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783837/ https://www.ncbi.nlm.nih.gov/pubmed/33424360 http://dx.doi.org/10.1016/j.sjbs.2020.10.065 |
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