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Deep Venous Thrombosis in COVID-19 Patients: A Cohort Analysis
Deep venous thrombosis (DVT) is a severe complication of coronavirus disease 2019 (COVID-19). The purpose of this study was to study the prevalence, risk factors, anticoagulant therapy and sex differences of DVT in patients with COVID-19. The enrolled 121 hospitalized non-ventilator patients were co...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783883/ https://www.ncbi.nlm.nih.gov/pubmed/33372807 http://dx.doi.org/10.1177/1076029620982669 |
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author | Cai, Chuanqi Guo, Yi You, Yun Hu, Ke Cai, Fei Xie, Mingxing Yang, Lu Ling, Ken Ye, Dawei Misra, Sanjay Wang, Weici Li, Yiqing |
author_facet | Cai, Chuanqi Guo, Yi You, Yun Hu, Ke Cai, Fei Xie, Mingxing Yang, Lu Ling, Ken Ye, Dawei Misra, Sanjay Wang, Weici Li, Yiqing |
author_sort | Cai, Chuanqi |
collection | PubMed |
description | Deep venous thrombosis (DVT) is a severe complication of coronavirus disease 2019 (COVID-19). The purpose of this study was to study the prevalence, risk factors, anticoagulant therapy and sex differences of DVT in patients with COVID-19. The enrolled 121 hospitalized non-ventilator patients were confirmed positive for COVID-19. All suspected patients received color Doppler ultrasound (US) to screen for DVT in both lower extremities. Multivariate logistic regression was performed to identify risk factors related to DVT in COVID-19 patients. DVT was found in 48% of the asymptomatic COVID-19 patients with an increased PADUA or Caprini index using US scanning. The multivariate logistic regression determined that age (OR, 1.05; p = .0306), C-reactive protein (CRP) (OR, 1.02; p = .0040), and baseline D-dimer (OR, 1.42; p = .0010) were risk factors among COVID-19 patients. Although the most common DVT location was infrapopliteal (classes I and II), higher mortality in DVT-COVID-19 patients was confirmed. DVT-COVID-19 patients presented significant increases in CRP, neutrophil count, and D-dimer throughout the whole inpatient period compared to non-DVT-COVID-19 patients. Although anticoagulation therapy accelerated the recovery of lymphocytopenia in DVT patients, men DVT-COVID-19 patients with anticoagulant therapy showed significant higher CRP and neutrophil count vs. lymphocyte count (N/L) ratio, but showed lower lymphocyte counts compared to women DVT-COVID-19 patients. DVT is common in COVID-19 patients with high-risk factors, especially for older age and higher CRP and baseline D-dimer populations. It is important to consider sex differences in anticoagulant therapy among DVT-COVID-19 patients. |
format | Online Article Text |
id | pubmed-7783883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77838832021-01-14 Deep Venous Thrombosis in COVID-19 Patients: A Cohort Analysis Cai, Chuanqi Guo, Yi You, Yun Hu, Ke Cai, Fei Xie, Mingxing Yang, Lu Ling, Ken Ye, Dawei Misra, Sanjay Wang, Weici Li, Yiqing Clin Appl Thromb Hemost COVID-19 Consensus Deep venous thrombosis (DVT) is a severe complication of coronavirus disease 2019 (COVID-19). The purpose of this study was to study the prevalence, risk factors, anticoagulant therapy and sex differences of DVT in patients with COVID-19. The enrolled 121 hospitalized non-ventilator patients were confirmed positive for COVID-19. All suspected patients received color Doppler ultrasound (US) to screen for DVT in both lower extremities. Multivariate logistic regression was performed to identify risk factors related to DVT in COVID-19 patients. DVT was found in 48% of the asymptomatic COVID-19 patients with an increased PADUA or Caprini index using US scanning. The multivariate logistic regression determined that age (OR, 1.05; p = .0306), C-reactive protein (CRP) (OR, 1.02; p = .0040), and baseline D-dimer (OR, 1.42; p = .0010) were risk factors among COVID-19 patients. Although the most common DVT location was infrapopliteal (classes I and II), higher mortality in DVT-COVID-19 patients was confirmed. DVT-COVID-19 patients presented significant increases in CRP, neutrophil count, and D-dimer throughout the whole inpatient period compared to non-DVT-COVID-19 patients. Although anticoagulation therapy accelerated the recovery of lymphocytopenia in DVT patients, men DVT-COVID-19 patients with anticoagulant therapy showed significant higher CRP and neutrophil count vs. lymphocyte count (N/L) ratio, but showed lower lymphocyte counts compared to women DVT-COVID-19 patients. DVT is common in COVID-19 patients with high-risk factors, especially for older age and higher CRP and baseline D-dimer populations. It is important to consider sex differences in anticoagulant therapy among DVT-COVID-19 patients. SAGE Publications 2020-12-29 /pmc/articles/PMC7783883/ /pubmed/33372807 http://dx.doi.org/10.1177/1076029620982669 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | COVID-19 Consensus Cai, Chuanqi Guo, Yi You, Yun Hu, Ke Cai, Fei Xie, Mingxing Yang, Lu Ling, Ken Ye, Dawei Misra, Sanjay Wang, Weici Li, Yiqing Deep Venous Thrombosis in COVID-19 Patients: A Cohort Analysis |
title | Deep Venous Thrombosis in COVID-19 Patients: A Cohort
Analysis |
title_full | Deep Venous Thrombosis in COVID-19 Patients: A Cohort
Analysis |
title_fullStr | Deep Venous Thrombosis in COVID-19 Patients: A Cohort
Analysis |
title_full_unstemmed | Deep Venous Thrombosis in COVID-19 Patients: A Cohort
Analysis |
title_short | Deep Venous Thrombosis in COVID-19 Patients: A Cohort
Analysis |
title_sort | deep venous thrombosis in covid-19 patients: a cohort
analysis |
topic | COVID-19 Consensus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783883/ https://www.ncbi.nlm.nih.gov/pubmed/33372807 http://dx.doi.org/10.1177/1076029620982669 |
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