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Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants

OBJECTIVE: This study aimed to evaluate the significance of urinary kidney injury molecule-1 (uKIM-1) levels in predicting acute kidney injury (AKI) and mortality in very low birth weight (VLBW) preterm infants. METHODS: This prospective, observational cohort study was conducted on 39 VLBW preterm i...

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Autores principales: Unal, Ebru Turkoglu, Ozer, Esra Arun, Kahramaner, Zelal, Erdemir, Aydin, Cosar, Hese, Sutcuoglu, Sumer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783886/
https://www.ncbi.nlm.nih.gov/pubmed/33372811
http://dx.doi.org/10.1177/0300060520977442
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author Unal, Ebru Turkoglu
Ozer, Esra Arun
Kahramaner, Zelal
Erdemir, Aydin
Cosar, Hese
Sutcuoglu, Sumer
author_facet Unal, Ebru Turkoglu
Ozer, Esra Arun
Kahramaner, Zelal
Erdemir, Aydin
Cosar, Hese
Sutcuoglu, Sumer
author_sort Unal, Ebru Turkoglu
collection PubMed
description OBJECTIVE: This study aimed to evaluate the significance of urinary kidney injury molecule-1 (uKIM-1) levels in predicting acute kidney injury (AKI) and mortality in very low birth weight (VLBW) preterm infants. METHODS: This prospective, observational cohort study was conducted on 39 VLBW preterm infants. Serum creatinine (SCr) and uKIM-1 levels were measured in the first 24 and 48 to 72 hours of life. The estimated glomerular filtration rate (eGFR) was calculated. Levels of uKIM-1 were measured with an enzyme-linked immunosorbent assay. RESULTS: Among 39 VLBW infants, 9 (23%) developed AKI. The mortality rate was 17.9% (n = 7 neonates). There was no significant difference in SCr levels, uKIM-1 levels, or the eGFR obtained in the first 24 hours in the AKI group compared with controls. However, significant differences were found in SCr and uKIM-1 levels, and the eGFR rate at 48 to 72 hours between the groups. Levels of uKIM-1 were significantly higher in non-survivors than in survivors in the first 24 and 48 to 72 hours of life. CONCLUSION: The level of uKIM-1 can be used as a simple noninvasive diagnostic method for predicting AKI and mortality, especially within 48 to 72 hours of life. Clinical trial registration: We do not have a clinical trial registration ID. In Turkey, clinical trial registration is not required for non-drug, noninvasive, clinical studies.
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spelling pubmed-77838862021-01-14 Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants Unal, Ebru Turkoglu Ozer, Esra Arun Kahramaner, Zelal Erdemir, Aydin Cosar, Hese Sutcuoglu, Sumer J Int Med Res Prospective Clinical Research Report OBJECTIVE: This study aimed to evaluate the significance of urinary kidney injury molecule-1 (uKIM-1) levels in predicting acute kidney injury (AKI) and mortality in very low birth weight (VLBW) preterm infants. METHODS: This prospective, observational cohort study was conducted on 39 VLBW preterm infants. Serum creatinine (SCr) and uKIM-1 levels were measured in the first 24 and 48 to 72 hours of life. The estimated glomerular filtration rate (eGFR) was calculated. Levels of uKIM-1 were measured with an enzyme-linked immunosorbent assay. RESULTS: Among 39 VLBW infants, 9 (23%) developed AKI. The mortality rate was 17.9% (n = 7 neonates). There was no significant difference in SCr levels, uKIM-1 levels, or the eGFR obtained in the first 24 hours in the AKI group compared with controls. However, significant differences were found in SCr and uKIM-1 levels, and the eGFR rate at 48 to 72 hours between the groups. Levels of uKIM-1 were significantly higher in non-survivors than in survivors in the first 24 and 48 to 72 hours of life. CONCLUSION: The level of uKIM-1 can be used as a simple noninvasive diagnostic method for predicting AKI and mortality, especially within 48 to 72 hours of life. Clinical trial registration: We do not have a clinical trial registration ID. In Turkey, clinical trial registration is not required for non-drug, noninvasive, clinical studies. SAGE Publications 2020-12-29 /pmc/articles/PMC7783886/ /pubmed/33372811 http://dx.doi.org/10.1177/0300060520977442 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Unal, Ebru Turkoglu
Ozer, Esra Arun
Kahramaner, Zelal
Erdemir, Aydin
Cosar, Hese
Sutcuoglu, Sumer
Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
title Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
title_full Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
title_fullStr Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
title_full_unstemmed Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
title_short Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
title_sort value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783886/
https://www.ncbi.nlm.nih.gov/pubmed/33372811
http://dx.doi.org/10.1177/0300060520977442
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