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Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants
OBJECTIVE: This study aimed to evaluate the significance of urinary kidney injury molecule-1 (uKIM-1) levels in predicting acute kidney injury (AKI) and mortality in very low birth weight (VLBW) preterm infants. METHODS: This prospective, observational cohort study was conducted on 39 VLBW preterm i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783886/ https://www.ncbi.nlm.nih.gov/pubmed/33372811 http://dx.doi.org/10.1177/0300060520977442 |
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author | Unal, Ebru Turkoglu Ozer, Esra Arun Kahramaner, Zelal Erdemir, Aydin Cosar, Hese Sutcuoglu, Sumer |
author_facet | Unal, Ebru Turkoglu Ozer, Esra Arun Kahramaner, Zelal Erdemir, Aydin Cosar, Hese Sutcuoglu, Sumer |
author_sort | Unal, Ebru Turkoglu |
collection | PubMed |
description | OBJECTIVE: This study aimed to evaluate the significance of urinary kidney injury molecule-1 (uKIM-1) levels in predicting acute kidney injury (AKI) and mortality in very low birth weight (VLBW) preterm infants. METHODS: This prospective, observational cohort study was conducted on 39 VLBW preterm infants. Serum creatinine (SCr) and uKIM-1 levels were measured in the first 24 and 48 to 72 hours of life. The estimated glomerular filtration rate (eGFR) was calculated. Levels of uKIM-1 were measured with an enzyme-linked immunosorbent assay. RESULTS: Among 39 VLBW infants, 9 (23%) developed AKI. The mortality rate was 17.9% (n = 7 neonates). There was no significant difference in SCr levels, uKIM-1 levels, or the eGFR obtained in the first 24 hours in the AKI group compared with controls. However, significant differences were found in SCr and uKIM-1 levels, and the eGFR rate at 48 to 72 hours between the groups. Levels of uKIM-1 were significantly higher in non-survivors than in survivors in the first 24 and 48 to 72 hours of life. CONCLUSION: The level of uKIM-1 can be used as a simple noninvasive diagnostic method for predicting AKI and mortality, especially within 48 to 72 hours of life. Clinical trial registration: We do not have a clinical trial registration ID. In Turkey, clinical trial registration is not required for non-drug, noninvasive, clinical studies. |
format | Online Article Text |
id | pubmed-7783886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77838862021-01-14 Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants Unal, Ebru Turkoglu Ozer, Esra Arun Kahramaner, Zelal Erdemir, Aydin Cosar, Hese Sutcuoglu, Sumer J Int Med Res Prospective Clinical Research Report OBJECTIVE: This study aimed to evaluate the significance of urinary kidney injury molecule-1 (uKIM-1) levels in predicting acute kidney injury (AKI) and mortality in very low birth weight (VLBW) preterm infants. METHODS: This prospective, observational cohort study was conducted on 39 VLBW preterm infants. Serum creatinine (SCr) and uKIM-1 levels were measured in the first 24 and 48 to 72 hours of life. The estimated glomerular filtration rate (eGFR) was calculated. Levels of uKIM-1 were measured with an enzyme-linked immunosorbent assay. RESULTS: Among 39 VLBW infants, 9 (23%) developed AKI. The mortality rate was 17.9% (n = 7 neonates). There was no significant difference in SCr levels, uKIM-1 levels, or the eGFR obtained in the first 24 hours in the AKI group compared with controls. However, significant differences were found in SCr and uKIM-1 levels, and the eGFR rate at 48 to 72 hours between the groups. Levels of uKIM-1 were significantly higher in non-survivors than in survivors in the first 24 and 48 to 72 hours of life. CONCLUSION: The level of uKIM-1 can be used as a simple noninvasive diagnostic method for predicting AKI and mortality, especially within 48 to 72 hours of life. Clinical trial registration: We do not have a clinical trial registration ID. In Turkey, clinical trial registration is not required for non-drug, noninvasive, clinical studies. SAGE Publications 2020-12-29 /pmc/articles/PMC7783886/ /pubmed/33372811 http://dx.doi.org/10.1177/0300060520977442 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Prospective Clinical Research Report Unal, Ebru Turkoglu Ozer, Esra Arun Kahramaner, Zelal Erdemir, Aydin Cosar, Hese Sutcuoglu, Sumer Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants |
title | Value of urinary kidney injury molecule-1 levels in predicting acute
kidney injury in very low birth weight preterm infants |
title_full | Value of urinary kidney injury molecule-1 levels in predicting acute
kidney injury in very low birth weight preterm infants |
title_fullStr | Value of urinary kidney injury molecule-1 levels in predicting acute
kidney injury in very low birth weight preterm infants |
title_full_unstemmed | Value of urinary kidney injury molecule-1 levels in predicting acute
kidney injury in very low birth weight preterm infants |
title_short | Value of urinary kidney injury molecule-1 levels in predicting acute
kidney injury in very low birth weight preterm infants |
title_sort | value of urinary kidney injury molecule-1 levels in predicting acute
kidney injury in very low birth weight preterm infants |
topic | Prospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783886/ https://www.ncbi.nlm.nih.gov/pubmed/33372811 http://dx.doi.org/10.1177/0300060520977442 |
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