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Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study
OBJECTIVE: To investigate the association of folate and vitamin B(12) in early pregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS: The data of this study were from a subcohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cel...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Diabetes Association
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783943/ https://www.ncbi.nlm.nih.gov/pubmed/33158950 http://dx.doi.org/10.2337/dc20-1607 |
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author | Chen, Xiaotian Zhang, Yi Chen, Hongyan Jiang, Yuan Wang, Yin Wang, Dingmei Li, Mengru Dou, Yalan Sun, Xupeng Huang, Guoying Yan, Weili |
author_facet | Chen, Xiaotian Zhang, Yi Chen, Hongyan Jiang, Yuan Wang, Yin Wang, Dingmei Li, Mengru Dou, Yalan Sun, Xupeng Huang, Guoying Yan, Weili |
author_sort | Chen, Xiaotian |
collection | PubMed |
description | OBJECTIVE: To investigate the association of folate and vitamin B(12) in early pregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS: The data of this study were from a subcohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cell (RBC) folate and vitamin B(12) measurements at recruitment (between 9 and 13 gestational weeks) and those with three samples available for glucose measurements under an oral glucose tolerance test. GDM was diagnosed between 24 and 28 weeks’ gestation. Odds ratio (OR) and 95% CI of having GDM was used to quantify the association. RESULTS: A total of 1,058 pregnant women were included, and GDM occurred in 180 (17.01%). RBC folate and vitamin B(12) were significantly higher in pregnancies with GDM than those without GDM (P values were 0.045 and 0.002, respectively) and positively correlated with 1-h and 2-h serum glucose. Daily folic acid supplementation in early pregnancy increases the risk of GDM; OR (95% CI) was 1.73 (1.19–2.53) (P = 0.004). Compared with RBC folate <400 ng/mL, pregnancies with RBC folate ≥600 ng/mL were associated with ∼1.60-fold higher odds of GDM; the adjusted OR (95% CI) was 1.58 (1.03–2.41) (P = 0.033). A significant trend of risk effect on GDM risk across categories of RBC folate was observed (P(trend) = 0.021). Vitamin B(12) was significantly associated with GDM risk (OR 1.14 per 100 pg/mL; P = 0.002). No significant association of serum folate and percentile ratio of RBC folate/vitamin B(12) with GDM was observed. CONCLUSIONS: Higher maternal RBC folate and vitamin B(12) levels in early pregnancy are significantly associated with GDM risk, while the balance of folate/vitamin B(12) is not significantly associated with GDM. |
format | Online Article Text |
id | pubmed-7783943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-77839432021-01-12 Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study Chen, Xiaotian Zhang, Yi Chen, Hongyan Jiang, Yuan Wang, Yin Wang, Dingmei Li, Mengru Dou, Yalan Sun, Xupeng Huang, Guoying Yan, Weili Diabetes Care Cardiovascular and Metabolic Risk OBJECTIVE: To investigate the association of folate and vitamin B(12) in early pregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS: The data of this study were from a subcohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cell (RBC) folate and vitamin B(12) measurements at recruitment (between 9 and 13 gestational weeks) and those with three samples available for glucose measurements under an oral glucose tolerance test. GDM was diagnosed between 24 and 28 weeks’ gestation. Odds ratio (OR) and 95% CI of having GDM was used to quantify the association. RESULTS: A total of 1,058 pregnant women were included, and GDM occurred in 180 (17.01%). RBC folate and vitamin B(12) were significantly higher in pregnancies with GDM than those without GDM (P values were 0.045 and 0.002, respectively) and positively correlated with 1-h and 2-h serum glucose. Daily folic acid supplementation in early pregnancy increases the risk of GDM; OR (95% CI) was 1.73 (1.19–2.53) (P = 0.004). Compared with RBC folate <400 ng/mL, pregnancies with RBC folate ≥600 ng/mL were associated with ∼1.60-fold higher odds of GDM; the adjusted OR (95% CI) was 1.58 (1.03–2.41) (P = 0.033). A significant trend of risk effect on GDM risk across categories of RBC folate was observed (P(trend) = 0.021). Vitamin B(12) was significantly associated with GDM risk (OR 1.14 per 100 pg/mL; P = 0.002). No significant association of serum folate and percentile ratio of RBC folate/vitamin B(12) with GDM was observed. CONCLUSIONS: Higher maternal RBC folate and vitamin B(12) levels in early pregnancy are significantly associated with GDM risk, while the balance of folate/vitamin B(12) is not significantly associated with GDM. American Diabetes Association 2021-01 2020-11-06 /pmc/articles/PMC7783943/ /pubmed/33158950 http://dx.doi.org/10.2337/dc20-1607 Text en © 2020 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license. |
spellingShingle | Cardiovascular and Metabolic Risk Chen, Xiaotian Zhang, Yi Chen, Hongyan Jiang, Yuan Wang, Yin Wang, Dingmei Li, Mengru Dou, Yalan Sun, Xupeng Huang, Guoying Yan, Weili Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study |
title | Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study |
title_full | Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study |
title_fullStr | Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study |
title_full_unstemmed | Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study |
title_short | Association of Maternal Folate and Vitamin B(12) in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study |
title_sort | association of maternal folate and vitamin b(12) in early pregnancy with gestational diabetes mellitus: a prospective cohort study |
topic | Cardiovascular and Metabolic Risk |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783943/ https://www.ncbi.nlm.nih.gov/pubmed/33158950 http://dx.doi.org/10.2337/dc20-1607 |
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