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The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?

IMPORTANCE: Evidence emerged concerning how inflammatory arthritis and mood disorders can often occur in the same patient and show a similar clinical pattern. An overview of the rheumatological and psychiatric aspects of these diseases can certainly be useful for the improvement of patients' cl...

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Autores principales: Chimenti, Maria Sole, Fonti, Giulia Lavinia, Conigliaro, Paola, Triggianese, Paola, Bianciardi, Emanuela, Coviello, Marialuce, Lombardozzi, Ginevra, Tarantino, Giulia, Niolu, Cinzia, Siracusano, Alberto, Perricone, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783979/
https://www.ncbi.nlm.nih.gov/pubmed/33397417
http://dx.doi.org/10.1186/s12991-020-00322-2
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author Chimenti, Maria Sole
Fonti, Giulia Lavinia
Conigliaro, Paola
Triggianese, Paola
Bianciardi, Emanuela
Coviello, Marialuce
Lombardozzi, Ginevra
Tarantino, Giulia
Niolu, Cinzia
Siracusano, Alberto
Perricone, Roberto
author_facet Chimenti, Maria Sole
Fonti, Giulia Lavinia
Conigliaro, Paola
Triggianese, Paola
Bianciardi, Emanuela
Coviello, Marialuce
Lombardozzi, Ginevra
Tarantino, Giulia
Niolu, Cinzia
Siracusano, Alberto
Perricone, Roberto
author_sort Chimenti, Maria Sole
collection PubMed
description IMPORTANCE: Evidence emerged concerning how inflammatory arthritis and mood disorders can often occur in the same patient and show a similar clinical pattern. An overview of the rheumatological and psychiatric aspects of these diseases can certainly be useful for the improvement of patients' clinical and therapeutic management. OBJECTIVE: The aim of this narrative review was to summarize existing literature about common pathogenetic and clinical aspects as a means of improving management and therapeutic approach in patients affected by rheumatoid arthritis, psoriatic arthritis and spondyloarthritis. Outcomes such as disease activity indexes and patient reported outcomes (PROs) were considered. FINDINGS: Common pathogenetic pathways emerged between inflammatory arthritis and mood disorders. Pro-inflammatory mechanisms, such as TNFα, IL-6, IL-17 and oxidative stress factors as well as neurotransmitter alterations at the level of CNS and blood–brain barrier (BBB) cells are involved. The activation of these common pathogenetic pathways is, also, affected by the same triggers, such as smoking, stress, lifestyle, and evidence has emerged concerning the possibility of the clinical efficacy of using the same therapeutic approaches. CONCLUSIONS: The main causes of the variability in clinical studies outcomes are the rheumatological diseases considered, the prevalence of depression in the general population and in patients with rheumatological diseases and the type of depressive symptom examined. Patients affected by inflammatory arthritis can present symptoms and signs in common with mood disorders, leading to possible clinical overlap. There are still few studies analyzing this concept: they are extremely heterogeneous, both in the characteristics of the population taken into consideration and in the methods used for the definition of depressive disorder, but the suggestions of the data obtained so far are promising and deserve to be pursued.
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spelling pubmed-77839792021-01-05 The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation? Chimenti, Maria Sole Fonti, Giulia Lavinia Conigliaro, Paola Triggianese, Paola Bianciardi, Emanuela Coviello, Marialuce Lombardozzi, Ginevra Tarantino, Giulia Niolu, Cinzia Siracusano, Alberto Perricone, Roberto Ann Gen Psychiatry Review IMPORTANCE: Evidence emerged concerning how inflammatory arthritis and mood disorders can often occur in the same patient and show a similar clinical pattern. An overview of the rheumatological and psychiatric aspects of these diseases can certainly be useful for the improvement of patients' clinical and therapeutic management. OBJECTIVE: The aim of this narrative review was to summarize existing literature about common pathogenetic and clinical aspects as a means of improving management and therapeutic approach in patients affected by rheumatoid arthritis, psoriatic arthritis and spondyloarthritis. Outcomes such as disease activity indexes and patient reported outcomes (PROs) were considered. FINDINGS: Common pathogenetic pathways emerged between inflammatory arthritis and mood disorders. Pro-inflammatory mechanisms, such as TNFα, IL-6, IL-17 and oxidative stress factors as well as neurotransmitter alterations at the level of CNS and blood–brain barrier (BBB) cells are involved. The activation of these common pathogenetic pathways is, also, affected by the same triggers, such as smoking, stress, lifestyle, and evidence has emerged concerning the possibility of the clinical efficacy of using the same therapeutic approaches. CONCLUSIONS: The main causes of the variability in clinical studies outcomes are the rheumatological diseases considered, the prevalence of depression in the general population and in patients with rheumatological diseases and the type of depressive symptom examined. Patients affected by inflammatory arthritis can present symptoms and signs in common with mood disorders, leading to possible clinical overlap. There are still few studies analyzing this concept: they are extremely heterogeneous, both in the characteristics of the population taken into consideration and in the methods used for the definition of depressive disorder, but the suggestions of the data obtained so far are promising and deserve to be pursued. BioMed Central 2021-01-04 /pmc/articles/PMC7783979/ /pubmed/33397417 http://dx.doi.org/10.1186/s12991-020-00322-2 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chimenti, Maria Sole
Fonti, Giulia Lavinia
Conigliaro, Paola
Triggianese, Paola
Bianciardi, Emanuela
Coviello, Marialuce
Lombardozzi, Ginevra
Tarantino, Giulia
Niolu, Cinzia
Siracusano, Alberto
Perricone, Roberto
The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?
title The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?
title_full The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?
title_fullStr The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?
title_full_unstemmed The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?
title_short The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?
title_sort burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783979/
https://www.ncbi.nlm.nih.gov/pubmed/33397417
http://dx.doi.org/10.1186/s12991-020-00322-2
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