The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

BACKGROUND: Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein aggregation. A lead MT, called CLR01, has been demonstrated to inhibit the aggregation and toxicity of multiple amyloidogenic proteins in vitro and in vivo. Previously, we evaluated the effect of CLR01 in the 3 × ...

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Detalles Bibliográficos
Autores principales: Di, Jing, Siddique, Ibrar, Li, Zizheng, Malki, Ghattas, Hornung, Simon, Dutta, Suman, Hurst, Ian, Ishaaya, Ella, Wang, Austin, Tu, Sally, Boghos, Ani, Ericsson, Ida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784007/
https://www.ncbi.nlm.nih.gov/pubmed/33397489
http://dx.doi.org/10.1186/s13195-020-00743-x

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