Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level

Thyroid function is usually normal in differentiated thyroid carcinoma. We describe a case of a female patient who had metastatic follicular thyroid carcinoma (FTC) to the spine and lungs, who was clinically euthyroid but had very low free tetraiodothyronine (fT4) and normal thyroid stimulating horm...

Descripción completa

Detalles Bibliográficos
Autores principales: Loh, Leh Teng, Lim, Vivien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the ASEAN Federation of Endocrine Societies 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784090/
https://www.ncbi.nlm.nih.gov/pubmed/33442087
http://dx.doi.org/10.15605/jafes.032.01.11
_version_ 1783632234216947712
author Loh, Leh Teng
Lim, Vivien
author_facet Loh, Leh Teng
Lim, Vivien
author_sort Loh, Leh Teng
collection PubMed
description Thyroid function is usually normal in differentiated thyroid carcinoma. We describe a case of a female patient who had metastatic follicular thyroid carcinoma (FTC) to the spine and lungs, who was clinically euthyroid but had very low free tetraiodothyronine (fT4) and normal thyroid stimulating hormone (TSH). Free triiodothyronine (fT3) and total T3 (TT3) were normal. Levothyroxine treatment increased fT4 marginally but caused a two- to three-fold rise in fT3 and TT3 along with suppressed TSH. This is likely due to hyperconversion of T4 to T3 from elevation in D2 deiodinase activity in the tumor. This phenomenon has been reported to occur in about 20% of metastatic FTC.
format Online
Article
Text
id pubmed-7784090
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Journal of the ASEAN Federation of Endocrine Societies
record_format MEDLINE/PubMed
spelling pubmed-77840902021-01-12 Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level Loh, Leh Teng Lim, Vivien J ASEAN Fed Endocr Soc Case Report Thyroid function is usually normal in differentiated thyroid carcinoma. We describe a case of a female patient who had metastatic follicular thyroid carcinoma (FTC) to the spine and lungs, who was clinically euthyroid but had very low free tetraiodothyronine (fT4) and normal thyroid stimulating hormone (TSH). Free triiodothyronine (fT3) and total T3 (TT3) were normal. Levothyroxine treatment increased fT4 marginally but caused a two- to three-fold rise in fT3 and TT3 along with suppressed TSH. This is likely due to hyperconversion of T4 to T3 from elevation in D2 deiodinase activity in the tumor. This phenomenon has been reported to occur in about 20% of metastatic FTC. Journal of the ASEAN Federation of Endocrine Societies 2017-05-08 2017 /pmc/articles/PMC7784090/ /pubmed/33442087 http://dx.doi.org/10.15605/jafes.032.01.11 Text en © 2017 Journal of the ASEAN Federation of Endocrine Societies https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International.
spellingShingle Case Report
Loh, Leh Teng
Lim, Vivien
Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level
title Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level
title_full Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level
title_fullStr Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level
title_full_unstemmed Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level
title_short Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level
title_sort metastatic follicular thyroid carcinoma as a cause of low serum thyroxine with a normal thyroid stimulating hormone level
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784090/
https://www.ncbi.nlm.nih.gov/pubmed/33442087
http://dx.doi.org/10.15605/jafes.032.01.11
work_keys_str_mv AT lohlehteng metastaticfollicularthyroidcarcinomaasacauseoflowserumthyroxinewithanormalthyroidstimulatinghormonelevel
AT limvivien metastaticfollicularthyroidcarcinomaasacauseoflowserumthyroxinewithanormalthyroidstimulatinghormonelevel

Ejemplares similares