Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report

A 51-year-old Caucasian male developed Graves’ thyrotoxicosis following long-standing treatment for hypothyroidism. After a short period of treatment with carbimazole, he developed agranulocytosis and required total thyroidectomy. In this relevant case report, we review several pathogenetic mechanis...

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Detalles Bibliográficos
Autores principales: Clifford, Liam, Wakil, Ammar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the ASEAN Federation of Endocrine Societies 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784154/
https://www.ncbi.nlm.nih.gov/pubmed/33442126
http://dx.doi.org/10.15605/jafes.033.02.12
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author Clifford, Liam
Wakil, Ammar
author_facet Clifford, Liam
Wakil, Ammar
author_sort Clifford, Liam
collection PubMed
description A 51-year-old Caucasian male developed Graves’ thyrotoxicosis following long-standing treatment for hypothyroidism. After a short period of treatment with carbimazole, he developed agranulocytosis and required total thyroidectomy. In this relevant case report, we review several pathogenetic mechanisms that explain the transformation of autoimmune hypothyroidism into Graves’ disease and the possible approaches to the management of agranulocytosis secondary to antithyroid medications. Further studies are required to determine the best way to manage severe thyrotoxicosis when agranulocytosis develops due to antithyroid medications.
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spelling pubmed-77841542021-01-12 Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report Clifford, Liam Wakil, Ammar J ASEAN Fed Endocr Soc Case Report A 51-year-old Caucasian male developed Graves’ thyrotoxicosis following long-standing treatment for hypothyroidism. After a short period of treatment with carbimazole, he developed agranulocytosis and required total thyroidectomy. In this relevant case report, we review several pathogenetic mechanisms that explain the transformation of autoimmune hypothyroidism into Graves’ disease and the possible approaches to the management of agranulocytosis secondary to antithyroid medications. Further studies are required to determine the best way to manage severe thyrotoxicosis when agranulocytosis develops due to antithyroid medications. Journal of the ASEAN Federation of Endocrine Societies 2018-11-02 2018 /pmc/articles/PMC7784154/ /pubmed/33442126 http://dx.doi.org/10.15605/jafes.033.02.12 Text en © 2018 Journal of the ASEAN Federation of Endocrine Societies https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International.
spellingShingle Case Report
Clifford, Liam
Wakil, Ammar
Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report
title Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report
title_full Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report
title_fullStr Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report
title_full_unstemmed Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report
title_short Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report
title_sort conversion of primary hypothyroidism to hyperthyroidism: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784154/
https://www.ncbi.nlm.nih.gov/pubmed/33442126
http://dx.doi.org/10.15605/jafes.033.02.12
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