Bone Metabolism and Fracture Risk in Diabetes Mellitus

Individuals with Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are at increased risk for fragility fractures. Bone mineral density (BMD) is decreased in T1DM but often normal or even elevated in T2DM when compared with age-matched non-DM populations. However, bone turnover is d...

Descripción completa

Detalles Bibliográficos
Autores principales: Puspitasari, Melisa, Purnamasari, Dyah, Setyohadi, Bambang, Isbagio, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the ASEAN Federation of Endocrine Societies 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784240/
https://www.ncbi.nlm.nih.gov/pubmed/33442091
http://dx.doi.org/10.15605/jafes.032.02.14
_version_ 1783632269464829952
author Puspitasari, Melisa
Purnamasari, Dyah
Setyohadi, Bambang
Isbagio, Harry
author_facet Puspitasari, Melisa
Purnamasari, Dyah
Setyohadi, Bambang
Isbagio, Harry
author_sort Puspitasari, Melisa
collection PubMed
description Individuals with Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are at increased risk for fragility fractures. Bone mineral density (BMD) is decreased in T1DM but often normal or even elevated in T2DM when compared with age-matched non-DM populations. However, bone turnover is decreased in both T1DM and T2DM. The pathophysiologic mechanisms leading to bone fragility is multifactorial, and potentially leads to reduced bone formation, altered bone microstructure and decreased bone strength. Interestingly, different antidiabetic treatments may influence fracture risk due to effects on glycemic control, triggering of hypoglycemic events or osteoblastogenesis.
format Online
Article
Text
id pubmed-7784240
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Journal of the ASEAN Federation of Endocrine Societies
record_format MEDLINE/PubMed
spelling pubmed-77842402021-01-12 Bone Metabolism and Fracture Risk in Diabetes Mellitus Puspitasari, Melisa Purnamasari, Dyah Setyohadi, Bambang Isbagio, Harry J ASEAN Fed Endocr Soc Review Article Individuals with Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are at increased risk for fragility fractures. Bone mineral density (BMD) is decreased in T1DM but often normal or even elevated in T2DM when compared with age-matched non-DM populations. However, bone turnover is decreased in both T1DM and T2DM. The pathophysiologic mechanisms leading to bone fragility is multifactorial, and potentially leads to reduced bone formation, altered bone microstructure and decreased bone strength. Interestingly, different antidiabetic treatments may influence fracture risk due to effects on glycemic control, triggering of hypoglycemic events or osteoblastogenesis. Journal of the ASEAN Federation of Endocrine Societies 2017-10-15 2017 /pmc/articles/PMC7784240/ /pubmed/33442091 http://dx.doi.org/10.15605/jafes.032.02.14 Text en © 2017 Journal of the ASEAN Federation of Endocrine Societies https://creativecommons.org/licenses/by-nc/4.0/ Thsi work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International.
spellingShingle Review Article
Puspitasari, Melisa
Purnamasari, Dyah
Setyohadi, Bambang
Isbagio, Harry
Bone Metabolism and Fracture Risk in Diabetes Mellitus
title Bone Metabolism and Fracture Risk in Diabetes Mellitus
title_full Bone Metabolism and Fracture Risk in Diabetes Mellitus
title_fullStr Bone Metabolism and Fracture Risk in Diabetes Mellitus
title_full_unstemmed Bone Metabolism and Fracture Risk in Diabetes Mellitus
title_short Bone Metabolism and Fracture Risk in Diabetes Mellitus
title_sort bone metabolism and fracture risk in diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784240/
https://www.ncbi.nlm.nih.gov/pubmed/33442091
http://dx.doi.org/10.15605/jafes.032.02.14
work_keys_str_mv AT puspitasarimelisa bonemetabolismandfractureriskindiabetesmellitus
AT purnamasaridyah bonemetabolismandfractureriskindiabetesmellitus
AT setyohadibambang bonemetabolismandfractureriskindiabetesmellitus
AT isbagioharry bonemetabolismandfractureriskindiabetesmellitus

Ejemplares similares