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Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?

Cardiovascular regeneration aims to renew damaged or necrotic tissue and to enhance cardiac functional performance. Despite the hope arisen from the introduction and use of stem cells (SCs) as a novel cardiac regenerative approach, to-this-date, clinical trial findings are still ambivalent despite p...

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Detalles Bibliográficos
Autor principal: Constantinides, Christakis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784514/
https://www.ncbi.nlm.nih.gov/pubmed/33000632
http://dx.doi.org/10.1177/0963689720954434
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author Constantinides, Christakis
author_facet Constantinides, Christakis
author_sort Constantinides, Christakis
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description Cardiovascular regeneration aims to renew damaged or necrotic tissue and to enhance cardiac functional performance. Despite the hope arisen from the introduction and use of stem cells (SCs) as a novel cardiac regenerative approach, to-this-date, clinical trial findings are still ambivalent despite preclinical successes. Concurrently, noninvasive magnetic resonance imaging (MRI) advances have been based on nanotechnological breakthroughs that have (a) allowed fluorinated nanoparticles and ultrasmall iron oxide single-cell labeling, (b) explored imaging detection sensitivity limits (for preclinical/low-field clinical settings), and (c) accomplished cellular tracking in vivo. Nevertheless, outcomes have been far from ideal. Herein, the recently developed preclinical and clinical (1)H and (19)F MRI approaches for direct cardiac SC labeling techniques intended for cellular implantation and their potential for tracking these cells in health and infarcted states are summarized. To this extent, the potential preclinical and clinical values of (19)F MRI and tracking of SCs for cardiac regeneration in myocardial infarction are questioned and challenged.
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spelling pubmed-77845142021-01-14 Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? Constantinides, Christakis Cell Transplant Commentary Cardiovascular regeneration aims to renew damaged or necrotic tissue and to enhance cardiac functional performance. Despite the hope arisen from the introduction and use of stem cells (SCs) as a novel cardiac regenerative approach, to-this-date, clinical trial findings are still ambivalent despite preclinical successes. Concurrently, noninvasive magnetic resonance imaging (MRI) advances have been based on nanotechnological breakthroughs that have (a) allowed fluorinated nanoparticles and ultrasmall iron oxide single-cell labeling, (b) explored imaging detection sensitivity limits (for preclinical/low-field clinical settings), and (c) accomplished cellular tracking in vivo. Nevertheless, outcomes have been far from ideal. Herein, the recently developed preclinical and clinical (1)H and (19)F MRI approaches for direct cardiac SC labeling techniques intended for cellular implantation and their potential for tracking these cells in health and infarcted states are summarized. To this extent, the potential preclinical and clinical values of (19)F MRI and tracking of SCs for cardiac regeneration in myocardial infarction are questioned and challenged. SAGE Publications 2020-10-01 /pmc/articles/PMC7784514/ /pubmed/33000632 http://dx.doi.org/10.1177/0963689720954434 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Constantinides, Christakis
Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?
title Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?
title_full Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?
title_fullStr Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?
title_full_unstemmed Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?
title_short Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?
title_sort is there preclinical and clinical value for (19)f mri in stem cell cardiac regeneration?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784514/
https://www.ncbi.nlm.nih.gov/pubmed/33000632
http://dx.doi.org/10.1177/0963689720954434
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