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Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration?
Cardiovascular regeneration aims to renew damaged or necrotic tissue and to enhance cardiac functional performance. Despite the hope arisen from the introduction and use of stem cells (SCs) as a novel cardiac regenerative approach, to-this-date, clinical trial findings are still ambivalent despite p...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784514/ https://www.ncbi.nlm.nih.gov/pubmed/33000632 http://dx.doi.org/10.1177/0963689720954434 |
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author | Constantinides, Christakis |
author_facet | Constantinides, Christakis |
author_sort | Constantinides, Christakis |
collection | PubMed |
description | Cardiovascular regeneration aims to renew damaged or necrotic tissue and to enhance cardiac functional performance. Despite the hope arisen from the introduction and use of stem cells (SCs) as a novel cardiac regenerative approach, to-this-date, clinical trial findings are still ambivalent despite preclinical successes. Concurrently, noninvasive magnetic resonance imaging (MRI) advances have been based on nanotechnological breakthroughs that have (a) allowed fluorinated nanoparticles and ultrasmall iron oxide single-cell labeling, (b) explored imaging detection sensitivity limits (for preclinical/low-field clinical settings), and (c) accomplished cellular tracking in vivo. Nevertheless, outcomes have been far from ideal. Herein, the recently developed preclinical and clinical (1)H and (19)F MRI approaches for direct cardiac SC labeling techniques intended for cellular implantation and their potential for tracking these cells in health and infarcted states are summarized. To this extent, the potential preclinical and clinical values of (19)F MRI and tracking of SCs for cardiac regeneration in myocardial infarction are questioned and challenged. |
format | Online Article Text |
id | pubmed-7784514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77845142021-01-14 Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? Constantinides, Christakis Cell Transplant Commentary Cardiovascular regeneration aims to renew damaged or necrotic tissue and to enhance cardiac functional performance. Despite the hope arisen from the introduction and use of stem cells (SCs) as a novel cardiac regenerative approach, to-this-date, clinical trial findings are still ambivalent despite preclinical successes. Concurrently, noninvasive magnetic resonance imaging (MRI) advances have been based on nanotechnological breakthroughs that have (a) allowed fluorinated nanoparticles and ultrasmall iron oxide single-cell labeling, (b) explored imaging detection sensitivity limits (for preclinical/low-field clinical settings), and (c) accomplished cellular tracking in vivo. Nevertheless, outcomes have been far from ideal. Herein, the recently developed preclinical and clinical (1)H and (19)F MRI approaches for direct cardiac SC labeling techniques intended for cellular implantation and their potential for tracking these cells in health and infarcted states are summarized. To this extent, the potential preclinical and clinical values of (19)F MRI and tracking of SCs for cardiac regeneration in myocardial infarction are questioned and challenged. SAGE Publications 2020-10-01 /pmc/articles/PMC7784514/ /pubmed/33000632 http://dx.doi.org/10.1177/0963689720954434 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Commentary Constantinides, Christakis Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? |
title | Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? |
title_full | Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? |
title_fullStr | Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? |
title_full_unstemmed | Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? |
title_short | Is There Preclinical and Clinical Value for (19)F MRI in Stem Cell Cardiac Regeneration? |
title_sort | is there preclinical and clinical value for (19)f mri in stem cell cardiac regeneration? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784514/ https://www.ncbi.nlm.nih.gov/pubmed/33000632 http://dx.doi.org/10.1177/0963689720954434 |
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