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The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder

While Parkinson’s disease (PD) and attention-deficit hyperactivity disorder (ADHD) are two distinct conditions, it has been hypothesized that they share several overlapping anatomical and neurochemical changes. In order to investigate that hypothesis, this study used claims data from Taiwan’s Longit...

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Autores principales: Fan, Hueng-Chuen, Chang, Yu-Kang, Tsai, Jeng-Dau, Chiang, Kuo-Liang, Shih, Jui-Hu, Yeh, Kuan-Yi, Ma, Kuo-Hsing, Li, I-Hsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784516/
https://www.ncbi.nlm.nih.gov/pubmed/33028106
http://dx.doi.org/10.1177/0963689720947416
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author Fan, Hueng-Chuen
Chang, Yu-Kang
Tsai, Jeng-Dau
Chiang, Kuo-Liang
Shih, Jui-Hu
Yeh, Kuan-Yi
Ma, Kuo-Hsing
Li, I-Hsun
author_facet Fan, Hueng-Chuen
Chang, Yu-Kang
Tsai, Jeng-Dau
Chiang, Kuo-Liang
Shih, Jui-Hu
Yeh, Kuan-Yi
Ma, Kuo-Hsing
Li, I-Hsun
author_sort Fan, Hueng-Chuen
collection PubMed
description While Parkinson’s disease (PD) and attention-deficit hyperactivity disorder (ADHD) are two distinct conditions, it has been hypothesized that they share several overlapping anatomical and neurochemical changes. In order to investigate that hypothesis, this study used claims data from Taiwan’s Longitudinal Health Insurance Database 2000 to provide the significant nationwide population-based evidence of an increased risk of PD among ADHD patients, and the connection between the two conditions was not the result of other comorbidities. Moreover, this study showed that the patients with PD were 2.8 times more likely to have a prior ADHD diagnosis compared with those without a prior history of ADHD. Furthermore, an animal model of ADHD was generated by neonatally injecting rats with 6-hydroxydopamine (6-OHDA). These rats were subjected to behavior tests and the 99mTc-TRODAT-1 brain imaging at the juvenile stage. Compared to control group rats, the 6-OHDA rats showed a significantly reduced specific uptake ratio in the striatum, indicating an underlying PD-linked pathology in the brains of these ADHD phenotype-expressing rats. Overall, these results support that ADHD shares a number of anatomical and neurochemical changes with PD. As such, improved knowledge of the neurochemical mechanisms underlying ADHD could result in improved treatments for various debilitating neurological disorders, including PD.
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spelling pubmed-77845162021-01-14 The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder Fan, Hueng-Chuen Chang, Yu-Kang Tsai, Jeng-Dau Chiang, Kuo-Liang Shih, Jui-Hu Yeh, Kuan-Yi Ma, Kuo-Hsing Li, I-Hsun Cell Transplant Original Article While Parkinson’s disease (PD) and attention-deficit hyperactivity disorder (ADHD) are two distinct conditions, it has been hypothesized that they share several overlapping anatomical and neurochemical changes. In order to investigate that hypothesis, this study used claims data from Taiwan’s Longitudinal Health Insurance Database 2000 to provide the significant nationwide population-based evidence of an increased risk of PD among ADHD patients, and the connection between the two conditions was not the result of other comorbidities. Moreover, this study showed that the patients with PD were 2.8 times more likely to have a prior ADHD diagnosis compared with those without a prior history of ADHD. Furthermore, an animal model of ADHD was generated by neonatally injecting rats with 6-hydroxydopamine (6-OHDA). These rats were subjected to behavior tests and the 99mTc-TRODAT-1 brain imaging at the juvenile stage. Compared to control group rats, the 6-OHDA rats showed a significantly reduced specific uptake ratio in the striatum, indicating an underlying PD-linked pathology in the brains of these ADHD phenotype-expressing rats. Overall, these results support that ADHD shares a number of anatomical and neurochemical changes with PD. As such, improved knowledge of the neurochemical mechanisms underlying ADHD could result in improved treatments for various debilitating neurological disorders, including PD. SAGE Publications 2020-10-07 /pmc/articles/PMC7784516/ /pubmed/33028106 http://dx.doi.org/10.1177/0963689720947416 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Fan, Hueng-Chuen
Chang, Yu-Kang
Tsai, Jeng-Dau
Chiang, Kuo-Liang
Shih, Jui-Hu
Yeh, Kuan-Yi
Ma, Kuo-Hsing
Li, I-Hsun
The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder
title The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder
title_full The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder
title_fullStr The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder
title_full_unstemmed The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder
title_short The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder
title_sort association between parkinson’s disease and attention-deficit hyperactivity disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784516/
https://www.ncbi.nlm.nih.gov/pubmed/33028106
http://dx.doi.org/10.1177/0963689720947416
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