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Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma

Secreted frizzled-related proteins (SFRPs) are a group of five secreted glycoproteins—SFRP1, SFRP2, SFRP3 (frizzled related protein, FRZB), SFRP4, and SFRP5—which contain a frizzled-related cysteine-rich domain and a netrin module. We analyzed SFRPs’ expression levels, mutations, regulation, functio...

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Autores principales: Wu, Zeng-Hong, Zhang, You-jing, Yue, Jian-Xin, Zhou, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784597/
https://www.ncbi.nlm.nih.gov/pubmed/32990024
http://dx.doi.org/10.1177/0963689720962479
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author Wu, Zeng-Hong
Zhang, You-jing
Yue, Jian-Xin
Zhou, Tao
author_facet Wu, Zeng-Hong
Zhang, You-jing
Yue, Jian-Xin
Zhou, Tao
author_sort Wu, Zeng-Hong
collection PubMed
description Secreted frizzled-related proteins (SFRPs) are a group of five secreted glycoproteins—SFRP1, SFRP2, SFRP3 (frizzled related protein, FRZB), SFRP4, and SFRP5—which contain a frizzled-related cysteine-rich domain and a netrin module. We analyzed SFRPs’ expression levels, mutations, regulation, functional networks, and correlation with immune infiltration in breast cancer (BC) patients using data from multiple open databases. SFRP1/3/4/5 were downregulated and SFRP2 was upregulated in BC patients compared to healthy controls. Furthermore, higher levels of SFRP1/3/4 were significantly associated with favorable prognosis. In addition, the prognostic significance of the infiltrating B cells was correlated to the SFRPs. Based on these findings, we hypothesize that SFRPs play a synergistic role in BC progression, and are, therefore, promising prognostic biomarkers as well as therapeutic targets.
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spelling pubmed-77845972021-01-14 Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma Wu, Zeng-Hong Zhang, You-jing Yue, Jian-Xin Zhou, Tao Cell Transplant Original Article Secreted frizzled-related proteins (SFRPs) are a group of five secreted glycoproteins—SFRP1, SFRP2, SFRP3 (frizzled related protein, FRZB), SFRP4, and SFRP5—which contain a frizzled-related cysteine-rich domain and a netrin module. We analyzed SFRPs’ expression levels, mutations, regulation, functional networks, and correlation with immune infiltration in breast cancer (BC) patients using data from multiple open databases. SFRP1/3/4/5 were downregulated and SFRP2 was upregulated in BC patients compared to healthy controls. Furthermore, higher levels of SFRP1/3/4 were significantly associated with favorable prognosis. In addition, the prognostic significance of the infiltrating B cells was correlated to the SFRPs. Based on these findings, we hypothesize that SFRPs play a synergistic role in BC progression, and are, therefore, promising prognostic biomarkers as well as therapeutic targets. SAGE Publications 2020-09-29 /pmc/articles/PMC7784597/ /pubmed/32990024 http://dx.doi.org/10.1177/0963689720962479 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Wu, Zeng-Hong
Zhang, You-jing
Yue, Jian-Xin
Zhou, Tao
Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma
title Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma
title_full Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma
title_fullStr Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma
title_full_unstemmed Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma
title_short Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma
title_sort comprehensive analysis of the expression and prognosis for sfrps in breast carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784597/
https://www.ncbi.nlm.nih.gov/pubmed/32990024
http://dx.doi.org/10.1177/0963689720962479
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