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An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19
This paper stresses its base contribution on a new SIR-type model including direct and fomite transmission as well as the effect of distinct household structures. The model derivation is modulated by several mechanistic processes inherent from typical airborne diseases. The notion of minimum contact...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784626/ https://www.ncbi.nlm.nih.gov/pubmed/33425640 http://dx.doi.org/10.1186/s13362-020-00097-x |
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author | Wijaya, Karunia Putra Ganegoda, Naleen Jayathunga, Yashika Götz, Thomas Schäfer, Moritz Heidrich, Peter |
author_facet | Wijaya, Karunia Putra Ganegoda, Naleen Jayathunga, Yashika Götz, Thomas Schäfer, Moritz Heidrich, Peter |
author_sort | Wijaya, Karunia Putra |
collection | PubMed |
description | This paper stresses its base contribution on a new SIR-type model including direct and fomite transmission as well as the effect of distinct household structures. The model derivation is modulated by several mechanistic processes inherent from typical airborne diseases. The notion of minimum contact radius is included in the direct transmission, facilitating the arguments on physical distancing. As fomite transmission heavily relates to former-trace of sneezes, the vector field of the system naturally contains an integral kernel with time delay indicating the contribution of undetected and non-quarantined asymptomatic cases in accumulating the historical contamination of surfaces. We then increase the complexity by including the different transmission routines within and between households. For airborne diseases, within-household interactions play a significant role in the propagation of the disease rendering countrywide effect. Two steps were taken to include the effect of household structure. The first step subdivides the entire compartments (susceptible, exposed, asymptomatic, symptomatic, recovered, death) into the household level and different infection rates for the direct transmission within and between households were distinguished. Under predefined conditions and assumptions, the governing system on household level can be raised to the community level. The second step then raises the governing system to the country level, where the final state variables estimate the total individuals from all compartments in the country. Two key attributes related to the household structure (number of local households and number of household members) effectively classify countries to be of low or high risk in terms of effective disease propagation. The basic reproductive number is calculated and its biological meaning is invoked properly. The numerical methods for solving the DIDE-system and the parameter estimation problem were mentioned. Our optimal model solutions are in quite good agreement with datasets of COVID-19 active cases and related deaths from Germany and Sri Lanka in early infection, allowing us to hypothesize several unobservable situations in the two countries. Focusing on extending minimum contact radius and reducing the intensity of individual activities, we were able to synthesize the key parameters telling what to practice. |
format | Online Article Text |
id | pubmed-7784626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-77846262021-01-06 An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19 Wijaya, Karunia Putra Ganegoda, Naleen Jayathunga, Yashika Götz, Thomas Schäfer, Moritz Heidrich, Peter J Math Ind Research This paper stresses its base contribution on a new SIR-type model including direct and fomite transmission as well as the effect of distinct household structures. The model derivation is modulated by several mechanistic processes inherent from typical airborne diseases. The notion of minimum contact radius is included in the direct transmission, facilitating the arguments on physical distancing. As fomite transmission heavily relates to former-trace of sneezes, the vector field of the system naturally contains an integral kernel with time delay indicating the contribution of undetected and non-quarantined asymptomatic cases in accumulating the historical contamination of surfaces. We then increase the complexity by including the different transmission routines within and between households. For airborne diseases, within-household interactions play a significant role in the propagation of the disease rendering countrywide effect. Two steps were taken to include the effect of household structure. The first step subdivides the entire compartments (susceptible, exposed, asymptomatic, symptomatic, recovered, death) into the household level and different infection rates for the direct transmission within and between households were distinguished. Under predefined conditions and assumptions, the governing system on household level can be raised to the community level. The second step then raises the governing system to the country level, where the final state variables estimate the total individuals from all compartments in the country. Two key attributes related to the household structure (number of local households and number of household members) effectively classify countries to be of low or high risk in terms of effective disease propagation. The basic reproductive number is calculated and its biological meaning is invoked properly. The numerical methods for solving the DIDE-system and the parameter estimation problem were mentioned. Our optimal model solutions are in quite good agreement with datasets of COVID-19 active cases and related deaths from Germany and Sri Lanka in early infection, allowing us to hypothesize several unobservable situations in the two countries. Focusing on extending minimum contact radius and reducing the intensity of individual activities, we were able to synthesize the key parameters telling what to practice. Springer Berlin Heidelberg 2021-01-05 2021 /pmc/articles/PMC7784626/ /pubmed/33425640 http://dx.doi.org/10.1186/s13362-020-00097-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Wijaya, Karunia Putra Ganegoda, Naleen Jayathunga, Yashika Götz, Thomas Schäfer, Moritz Heidrich, Peter An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19 |
title | An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19 |
title_full | An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19 |
title_fullStr | An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19 |
title_full_unstemmed | An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19 |
title_short | An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19 |
title_sort | epidemic model integrating direct and fomite transmission as well as household structure applied to covid-19 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784626/ https://www.ncbi.nlm.nih.gov/pubmed/33425640 http://dx.doi.org/10.1186/s13362-020-00097-x |
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