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Hydride Transfer Catalyzed by Glycerol Phosphate Dehydrogenase: Recruitment of an Acidic Amino Acid Side Chain to Rescue a Damaged Enzyme

[Image: see text] K120 of glycerol 3-phosphate dehydrogenase (GPDH) lies close to the carbonyl group of the bound dihydroxyacetone phosphate (DHAP) dianion. pH rate (pH 4.6–9.0) profiles are reported for k(cat) and (k(cat)/K(m))(dianion) for wild type and K120A GPDH-catalyzed reduction of DHAP by NA...

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Detalles Bibliográficos
Autores principales:	He, Rui, Cristobal, Judith R., Gong, Naiji Jabin, Richard, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784668/ https://www.ncbi.nlm.nih.gov/pubmed/33305938 http://dx.doi.org/10.1021/acs.biochem.0c00801

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