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An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases

In COVID-19, the inflammatory cytokine-release syndrome is associated with the progression of the disease. Itolizumab is a monoclonal antibody that recognizes human CD6 expressed in activated T cells. The antibody has shown to be safe and efficacious in the treatment of moderate to severe psoriasis....

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Detalles Bibliográficos
Autores principales: Filgueira, Lázaro Manuel, Cervantes, Julio Betancourt, Lovelle, Orlando Adolfo, Herrera, Carlos, Figueredo, Carlos, Caballero, Jorge Alain, Sánchez, Naivy, Berrio, Jorge, Lorenzo, Geidy, Cepeda, Meylan, Ramos, Mayra, Saavedra, Danay, Añe-Kouri, Ana Laura, Mazorra, Zaima, Leon, Kalet, Crombet, Tania, Caballero, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784786/
https://www.ncbi.nlm.nih.gov/pubmed/33397150
http://dx.doi.org/10.2217/imt-2020-0235
Descripción
Sumario:In COVID-19, the inflammatory cytokine-release syndrome is associated with the progression of the disease. Itolizumab is a monoclonal antibody that recognizes human CD6 expressed in activated T cells. The antibody has shown to be safe and efficacious in the treatment of moderate to severe psoriasis. Its effect is associated with the reduction of pro-inflammatory cytokines release, including IFN-γ, IL-6 and TNF-α. Here, we report the outcome of three severe and critically ill COVID-19 patients treated with itolizumab as part of an expanded access protocol. Itolizumab was able to reduce IL-6 concentrations in all the patients. Two of the three patients showed respiratory and radiological improvement and were fully recovered. We hypothesize this anti-inflammatory therapy in addition to antiviral and anticoagulant therapy could reduce COVID-19 associated morbidity and mortality.