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Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β

Despite their mutual antagonism, inflammation and immunosuppression coexist in tumor microenvironments due to tumor and immune cell interactions, but the underlying mechanism remains unclear. Previously, we showed that tumor cell-derived microparticles induce an M2 phenotype characterized by immunos...

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Autores principales: Chen, Jie, Sun, Weiwei, Zhang, Huafeng, Ma, Jingwei, Xu, Pingwei, Yu, Yuandong, Fang, Haiqing, Zhou, Li, Lv, Jiadi, Xie, Jing, Liu, Yuying, Tang, Ke, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784894/
https://www.ncbi.nlm.nih.gov/pubmed/31649305
http://dx.doi.org/10.1038/s41423-019-0313-2
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author Chen, Jie
Sun, Weiwei
Zhang, Huafeng
Ma, Jingwei
Xu, Pingwei
Yu, Yuandong
Fang, Haiqing
Zhou, Li
Lv, Jiadi
Xie, Jing
Liu, Yuying
Tang, Ke
Huang, Bo
author_facet Chen, Jie
Sun, Weiwei
Zhang, Huafeng
Ma, Jingwei
Xu, Pingwei
Yu, Yuandong
Fang, Haiqing
Zhou, Li
Lv, Jiadi
Xie, Jing
Liu, Yuying
Tang, Ke
Huang, Bo
author_sort Chen, Jie
collection PubMed
description Despite their mutual antagonism, inflammation and immunosuppression coexist in tumor microenvironments due to tumor and immune cell interactions, but the underlying mechanism remains unclear. Previously, we showed that tumor cell-derived microparticles induce an M2 phenotype characterized by immunosuppression in tumor-infiltrating macrophages. Here, we further showed that lung cancer microparticles (L-MPs) induce macrophages to release a key proinflammatory cytokine, IL-1β, thus promoting lung cancer development. The underlying mechanism involves the activation of TLR3 and the NLRP3 inflammasome by L-MPs. More importantly, tyrosine kinase inhibitor treatment-induced L-MPs also induce human macrophages to release IL-1β, leading to a tumor-promoting effect in a humanized mouse model. These findings demonstrated that in addition to their anti-inflammatory effect, L-MPs induce a proinflammatory phenotype in tumor-infiltrating macrophages, promoting the development of inflammatory and immunosuppressive tumor microenvironments.
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spelling pubmed-77848942021-01-14 Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β Chen, Jie Sun, Weiwei Zhang, Huafeng Ma, Jingwei Xu, Pingwei Yu, Yuandong Fang, Haiqing Zhou, Li Lv, Jiadi Xie, Jing Liu, Yuying Tang, Ke Huang, Bo Cell Mol Immunol Article Despite their mutual antagonism, inflammation and immunosuppression coexist in tumor microenvironments due to tumor and immune cell interactions, but the underlying mechanism remains unclear. Previously, we showed that tumor cell-derived microparticles induce an M2 phenotype characterized by immunosuppression in tumor-infiltrating macrophages. Here, we further showed that lung cancer microparticles (L-MPs) induce macrophages to release a key proinflammatory cytokine, IL-1β, thus promoting lung cancer development. The underlying mechanism involves the activation of TLR3 and the NLRP3 inflammasome by L-MPs. More importantly, tyrosine kinase inhibitor treatment-induced L-MPs also induce human macrophages to release IL-1β, leading to a tumor-promoting effect in a humanized mouse model. These findings demonstrated that in addition to their anti-inflammatory effect, L-MPs induce a proinflammatory phenotype in tumor-infiltrating macrophages, promoting the development of inflammatory and immunosuppressive tumor microenvironments. Nature Publishing Group UK 2019-10-24 2020-12 /pmc/articles/PMC7784894/ /pubmed/31649305 http://dx.doi.org/10.1038/s41423-019-0313-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Jie
Sun, Weiwei
Zhang, Huafeng
Ma, Jingwei
Xu, Pingwei
Yu, Yuandong
Fang, Haiqing
Zhou, Li
Lv, Jiadi
Xie, Jing
Liu, Yuying
Tang, Ke
Huang, Bo
Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β
title Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β
title_full Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β
title_fullStr Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β
title_full_unstemmed Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β
title_short Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β
title_sort macrophages reprogrammed by lung cancer microparticles promote tumor development via release of il-1β
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784894/
https://www.ncbi.nlm.nih.gov/pubmed/31649305
http://dx.doi.org/10.1038/s41423-019-0313-2
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