Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

CD8(+) T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance. Immune checkpoint...

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Detalles Bibliográficos
Autores principales: Lv, Mengze, Chen, Meixia, Zhang, Rui, Zhang, Wen, Wang, Chenguang, Zhang, Yan, Wei, Xiaoming, Guan, Yukun, Liu, Jiejie, Feng, Kaichao, Jing, Miao, Wang, Xurui, Liu, Yun-Cai, Mei, Qian, Han, Weidong, Jiang, Zhengfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785004/
https://www.ncbi.nlm.nih.gov/pubmed/32839553
http://dx.doi.org/10.1038/s41422-020-00395-4

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