Nox2 signaling and muscle fiber remodeling are attenuated by losartan administration during skeletal muscle unloading

Reduced mechanical loading results in atrophy of skeletal muscle fibers. Increased reactive oxygen species (ROS) are causal in sarcolemmal dislocation of nNOS and FoxO3a activation. The Nox2 isoform of NADPH oxidase and mitochondria release ROS during disuse in skeletal muscle. Activation of the ang...

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Detalles Bibliográficos
Autores principales: Hord, Jeffrey M., Garcia, Marcela M., Farris, Katherine R., Guzzoni, Vinicius, Lee, Yang, Lawler, Matthew S., Lawler, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785102/
https://www.ncbi.nlm.nih.gov/pubmed/33400850
http://dx.doi.org/10.14814/phy2.14606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785102/
https://www.ncbi.nlm.nih.gov/pubmed/33400850
http://dx.doi.org/10.14814/phy2.14606

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