Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has emerged as a central player in this process. Yet, we have limited understanding of how EMC enables insertion and integrity of di...

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Detalles Bibliográficos
Autores principales: Miller-Vedam, Lakshmi E, Bräuning, Bastian, Popova, Katerina D, Schirle Oakdale, Nicole T, Bonnar, Jessica L, Prabu, Jesuraj R, Boydston, Elizabeth A, Sevillano, Natalia, Shurtleff, Matthew J, Stroud, Robert M, Craik, Charles S, Schulman, Brenda A, Frost, Adam, Weissman, Jonathan S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785296/
https://www.ncbi.nlm.nih.gov/pubmed/33236988
http://dx.doi.org/10.7554/eLife.62611

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