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Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia

Candida bloodstream infection is the major cause of increased morbidity and mortality (20–49%) in hospitalized patients in both paediatric and adult age groups. Due to the increase in the number of immunocompromised patients, other important species such as Trichosporon asahii and Debaryomyces hanse...

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Autores principales: Mehta, Vibha, Mohanty, Aroop, Meena, Suneeta, Rahul, J. S., Uttam Kumar, Nath, Chattopadhyay, Debranjani, Bakliwal, Anamika, Choudhary, Ranjana, Gupta, Pratima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785382/
https://www.ncbi.nlm.nih.gov/pubmed/33457028
http://dx.doi.org/10.1155/2020/8847853
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author Mehta, Vibha
Mohanty, Aroop
Meena, Suneeta
Rahul, J. S.
Uttam Kumar, Nath
Chattopadhyay, Debranjani
Bakliwal, Anamika
Choudhary, Ranjana
Gupta, Pratima
author_facet Mehta, Vibha
Mohanty, Aroop
Meena, Suneeta
Rahul, J. S.
Uttam Kumar, Nath
Chattopadhyay, Debranjani
Bakliwal, Anamika
Choudhary, Ranjana
Gupta, Pratima
author_sort Mehta, Vibha
collection PubMed
description Candida bloodstream infection is the major cause of increased morbidity and mortality (20–49%) in hospitalized patients in both paediatric and adult age groups. Due to the increase in the number of immunocompromised patients, other important species such as Trichosporon asahii and Debaryomyces hansenii are emerging. One such organism, Wickerhamomyces anomalous, previously known as Pichia anomala (teleomorph stages of several Candida species), is increasingly being reported as a cause of fungemia in neonatal intensive care units and is now increasingly being reported in a lot of immunosuppressive conditions such as interstitial lung disease, endocarditis, enteritis, corticosteroids, and chemotherapy uptake. Though this yeast is ubiquitous in nature, systemic infections from isolated cases and sporadic outbreaks with high mortality have been reported in ICUs, which emphasize the importance to consider this fungus within the diagnostic possibilities. Here, we report a case of catheter-related bloodstream infection (CRBSI) caused by W. anomalus in a leukemic immunosuppressed patient who was successfully treated by early detection and treatment of this emerging fungus.
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spelling pubmed-77853822021-01-14 Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia Mehta, Vibha Mohanty, Aroop Meena, Suneeta Rahul, J. S. Uttam Kumar, Nath Chattopadhyay, Debranjani Bakliwal, Anamika Choudhary, Ranjana Gupta, Pratima Case Rep Infect Dis Case Report Candida bloodstream infection is the major cause of increased morbidity and mortality (20–49%) in hospitalized patients in both paediatric and adult age groups. Due to the increase in the number of immunocompromised patients, other important species such as Trichosporon asahii and Debaryomyces hansenii are emerging. One such organism, Wickerhamomyces anomalous, previously known as Pichia anomala (teleomorph stages of several Candida species), is increasingly being reported as a cause of fungemia in neonatal intensive care units and is now increasingly being reported in a lot of immunosuppressive conditions such as interstitial lung disease, endocarditis, enteritis, corticosteroids, and chemotherapy uptake. Though this yeast is ubiquitous in nature, systemic infections from isolated cases and sporadic outbreaks with high mortality have been reported in ICUs, which emphasize the importance to consider this fungus within the diagnostic possibilities. Here, we report a case of catheter-related bloodstream infection (CRBSI) caused by W. anomalus in a leukemic immunosuppressed patient who was successfully treated by early detection and treatment of this emerging fungus. Hindawi 2020-12-29 /pmc/articles/PMC7785382/ /pubmed/33457028 http://dx.doi.org/10.1155/2020/8847853 Text en Copyright © 2020 Vibha Mehta et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mehta, Vibha
Mohanty, Aroop
Meena, Suneeta
Rahul, J. S.
Uttam Kumar, Nath
Chattopadhyay, Debranjani
Bakliwal, Anamika
Choudhary, Ranjana
Gupta, Pratima
Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia
title Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia
title_full Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia
title_fullStr Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia
title_full_unstemmed Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia
title_short Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia
title_sort wickerhamomyces anomalous: a rare cause of fungemia causing febrile neutropenia in acute lymphoblastic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785382/
https://www.ncbi.nlm.nih.gov/pubmed/33457028
http://dx.doi.org/10.1155/2020/8847853
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