SARS-CoV-2: vaccines in the pandemic era

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As there is little or no natural immunity in the human population or specific anti-COVID-19 dr...

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Autores principales: Li, Dan-Dan, Li, Qi-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785400/
https://www.ncbi.nlm.nih.gov/pubmed/33402220
http://dx.doi.org/10.1186/s40779-020-00296-y
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author Li, Dan-Dan
Li, Qi-Han
author_facet Li, Dan-Dan
Li, Qi-Han
author_sort Li, Dan-Dan
collection PubMed
description Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As there is little or no natural immunity in the human population or specific anti-COVID-19 drugs, researchers from the government, academia and industry are developing vaccines at an unprecedented speed to halt the pandemic. In this review, the results of animal experiments and clinical trials on several vaccine technical platforms are summarized, and several challenges are also discussed to further promote the development, evaluation and application of vaccines during the challenging situation of the global pandemic.
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spelling pubmed-77854002021-01-06 SARS-CoV-2: vaccines in the pandemic era Li, Dan-Dan Li, Qi-Han Mil Med Res Review Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As there is little or no natural immunity in the human population or specific anti-COVID-19 drugs, researchers from the government, academia and industry are developing vaccines at an unprecedented speed to halt the pandemic. In this review, the results of animal experiments and clinical trials on several vaccine technical platforms are summarized, and several challenges are also discussed to further promote the development, evaluation and application of vaccines during the challenging situation of the global pandemic. BioMed Central 2021-01-06 /pmc/articles/PMC7785400/ /pubmed/33402220 http://dx.doi.org/10.1186/s40779-020-00296-y Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Dan-Dan
Li, Qi-Han
SARS-CoV-2: vaccines in the pandemic era
title SARS-CoV-2: vaccines in the pandemic era
title_full SARS-CoV-2: vaccines in the pandemic era
title_fullStr SARS-CoV-2: vaccines in the pandemic era
title_full_unstemmed SARS-CoV-2: vaccines in the pandemic era
title_short SARS-CoV-2: vaccines in the pandemic era
title_sort sars-cov-2: vaccines in the pandemic era
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785400/
https://www.ncbi.nlm.nih.gov/pubmed/33402220
http://dx.doi.org/10.1186/s40779-020-00296-y
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