Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly

The incidence of Clostridium difficile infection (CDI) has been decreasing in the last decade, though the incidence of community-acquired CDI has remained stable. In an elderly patient on Coumadin®, we report an unexpected decrease in international normalized ratio (INR) during the treatment of seco...

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Detalles Bibliográficos
Autores principales: Dhruv, Samyak, Polavarapu, Abhishek, Gumaste, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785468/
https://www.ncbi.nlm.nih.gov/pubmed/33425501
http://dx.doi.org/10.7759/cureus.11915
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author Dhruv, Samyak
Polavarapu, Abhishek
Gumaste, Vivek
author_facet Dhruv, Samyak
Polavarapu, Abhishek
Gumaste, Vivek
author_sort Dhruv, Samyak
collection PubMed
description The incidence of Clostridium difficile infection (CDI) has been decreasing in the last decade, though the incidence of community-acquired CDI has remained stable. In an elderly patient on Coumadin®, we report an unexpected decrease in international normalized ratio (INR) during the treatment of second recurrence of CDI treated with fidaxomicin. According to the available information, fidaxomicin does not interfere with warfarin. However, in this case, warfarin effects diminished, and only with increased dosage therapeutic INR was achieved.
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spelling pubmed-77854682021-01-07 Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly Dhruv, Samyak Polavarapu, Abhishek Gumaste, Vivek Cureus Internal Medicine The incidence of Clostridium difficile infection (CDI) has been decreasing in the last decade, though the incidence of community-acquired CDI has remained stable. In an elderly patient on Coumadin®, we report an unexpected decrease in international normalized ratio (INR) during the treatment of second recurrence of CDI treated with fidaxomicin. According to the available information, fidaxomicin does not interfere with warfarin. However, in this case, warfarin effects diminished, and only with increased dosage therapeutic INR was achieved. Cureus 2020-12-05 /pmc/articles/PMC7785468/ /pubmed/33425501 http://dx.doi.org/10.7759/cureus.11915 Text en Copyright © 2020, Dhruv et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Dhruv, Samyak
Polavarapu, Abhishek
Gumaste, Vivek
Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly
title Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly
title_full Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly
title_fullStr Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly
title_full_unstemmed Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly
title_short Fidaxomicin Use for Clostridium Difficile Infection Probably Decreases the Effect of Coumadin® in Elderly
title_sort fidaxomicin use for clostridium difficile infection probably decreases the effect of coumadin® in elderly
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785468/
https://www.ncbi.nlm.nih.gov/pubmed/33425501
http://dx.doi.org/10.7759/cureus.11915
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