Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation

T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we observe that human memory T cells are more sen...

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Detalles Bibliográficos
Autores principales: Glinos, Dafni A., Soskic, Blagoje, Williams, Cayman, Kennedy, Alan, Jostins, Luke, Sansom, David M., Trynka, Gosia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785515/
https://www.ncbi.nlm.nih.gov/pubmed/33223527
http://dx.doi.org/10.1038/s41435-020-00118-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785515/
https://www.ncbi.nlm.nih.gov/pubmed/33223527
http://dx.doi.org/10.1038/s41435-020-00118-0

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