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Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation
T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we observe that human memory T cells are more sen...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785515/ https://www.ncbi.nlm.nih.gov/pubmed/33223527 http://dx.doi.org/10.1038/s41435-020-00118-0 |