Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known to occur in recurrent IDH-mutant gliomas as resistance mechanism towards alkylating chemotherapy. In this multi-institutio...

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Detalles Bibliográficos
Autores principales: Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Kloor, Matthias, Wefers, Annika K., Reinhardt, Annekathrin, Maas, Sybren L. N., Kratz, Christian P., Schweizer, Leonille, Hasselblatt, Martin, Snuderl, Matija, Abedalthagafi, Malak Sameer J., Abdullaev, Zied, Monoranu, Camelia M., Bergmann, Markus, Pekrun, Arnulf, Freyschlag, Christian, Aronica, Eleonora, Kramm, Christof M., Hinz, Felix, Sievers, Philipp, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M., Sturm, Dominik, Jones, David T. W., Wick, Wolfgang, Unterberg, Andreas, Hartmann, Christian, Dodgshun, Andrew, Tabori, Uri, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Reuss, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785563/
https://www.ncbi.nlm.nih.gov/pubmed/33216206
http://dx.doi.org/10.1007/s00401-020-02243-6

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