Biased Influences of Low Tumor Purity on Mutation Detection in Cancer

The non-cancerous components in tumor tissues, e.g., infiltrating stromal cells and immune cells, dilute tumor purity and might confound genomic mutation profile analyses and the identification of pathological biomarkers. It is necessary to systematically evaluate the influence of tumor purity. Here...

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Detalles Bibliográficos
Autores principales: Cheng, Jun, He, Jun, Wang, Shanshan, Zhao, Zhangxiang, Yan, Haidan, Guan, Qingzhou, Li, Jing, Guo, Zheng, Ao, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785586/
https://www.ncbi.nlm.nih.gov/pubmed/33425983
http://dx.doi.org/10.3389/fmolb.2020.533196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785586/
https://www.ncbi.nlm.nih.gov/pubmed/33425983
http://dx.doi.org/10.3389/fmolb.2020.533196

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