Cargando…

Biased Influences of Low Tumor Purity on Mutation Detection in Cancer

The non-cancerous components in tumor tissues, e.g., infiltrating stromal cells and immune cells, dilute tumor purity and might confound genomic mutation profile analyses and the identification of pathological biomarkers. It is necessary to systematically evaluate the influence of tumor purity. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Jun, He, Jun, Wang, Shanshan, Zhao, Zhangxiang, Yan, Haidan, Guan, Qingzhou, Li, Jing, Guo, Zheng, Ao, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785586/ https://www.ncbi.nlm.nih.gov/pubmed/33425983 http://dx.doi.org/10.3389/fmolb.2020.533196

Ejemplares similares

A Qualitative Transcriptional Signature for Predicting Extreme Resistance of ER-Negative Breast Cancer to Paclitaxel, Doxorubicin, and Cyclophosphamide Neoadjuvant Chemotherapy
por: Chen, Yanhua, et al.
Publicado: (2020)

Identification of Tamoxifen-Resistant Breast Cancer Cell Lines and Drug Response Signature
por: Guan, Qingzhou, et al.
Publicado: (2020)

Influence of Disease-Causing Mutations on Protein Structural Networks
por: Prabantu, Vasam Manjveekar, et al.
Publicado: (2021)

Integrating Cycled Enzymatic DNA Amplification and Surface-Enhanced Raman Scattering for Sensitive Detection of Circulating Tumor DNA
por: Miao, Xinxing, et al.
Publicado: (2021)

DETECTing Merkel Cell Polyomavirus in Merkel Tumors
por: Arora, Reety, et al.
Publicado: (2020)

Multi-Omics Analysis of the Effects of Smoking on Human Tumors
por: Wang, Rui, et al.
Publicado: (2021)

PROT-ON: A structure-based detection of designer PROTein interface MutatiONs
por: Koşaca, Mehdi, et al.
Publicado: (2023)

A Qualitative Signature to Identify TERT Promoter Mutant High-Risk Tumors in Low-Grade Gliomas
por: Zheng, Weicheng, et al.
Publicado: (2022)

KRAS Mutation in Rare Tumors: A Landscape Analysis of 3453 Chinese Patients
por: Wang, Shuhang, et al.
Publicado: (2022)

Phosphatase and Tensin Homolog Mutation in Immune Cell Infiltration and Clinicopathological Features of Low-Grade Gliomas
por: Feng, Peng, et al.
Publicado: (2020)

Evaluating and Correcting Inherent Bias of microRNA Expression in Illumina Sequencing Analysis
por: Baroin-Tourancheau, Anne, et al.
Publicado: (2019)

Comprehensive Analysis of the Relationships Between Tumor Mutation Burden With Immune Infiltrates in Cervical Cell Carcinoma
por: Zhou, Cankun, et al.
Publicado: (2020)

Identification of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma Based on Multi-Omics Analysis
por: Yin, Lu, et al.
Publicado: (2021)

GCAT: A network model of mutational influences between amino acid positions in PSD95(pdz3)
por: Pacini, Lorenza, et al.
Publicado: (2022)

Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection
por: Liu, Yin, et al.
Publicado: (2021)

Editorial: Influence of mutations, stresses and post-translational modifications on the structure and function of heat shock proteins and their relationship with various diseases
por: Panda, Alok Kumar, et al.
Publicado: (2023)

UPLC-MS based integrated plasma proteomic and metabolomic profiling of TSC-RAML and its relationship with everolimus treatment
por: Wang, Zhan, et al.
Publicado: (2023)

Anncolvar: Approximation of Complex Collective Variables by Artificial Neural Networks for Analysis and Biasing of Molecular Simulations
por: Trapl, Dalibor, et al.
Publicado: (2019)

DESP: Deep Enhanced Sampling of Proteins’ Conformation Spaces Using AI-Inspired Biasing Forces
por: Salawu, Emmanuel Oluwatobi
Publicado: (2021)

Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties
por: Sala, Davide, et al.
Publicado: (2023)

Diagnostic Potential of Plasma IgA1 O-Glycans in Discriminating IgA Nephropathy From Other Glomerular Diseases and Healthy Participants
por: Zhang, Shuyu, et al.
Publicado: (2022)

Proteomic and Metabolomic Analyses of Right Ventricular Failure due to Pulmonary Arterial Hypertension
por: Qin, Xiaohan, et al.
Publicado: (2022)

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients
por: Huang, Tengda, et al.
Publicado: (2023)

Quantitative Proteomics Analysis of FFPE Tumor Samples Reveals the Influences of NET-1 siRNA Nanoparticles and Sonodynamic Therapy on Tetraspanin Protein Involved in HCC
por: Wu, Bolin, et al.
Publicado: (2021)

Unraveling the Influence of K280 Acetylation on the Conformational Features of Tau Core Fragment: A Molecular Dynamics Simulation Study
por: Zou, Yu, et al.
Publicado: (2021)

Automatic interictal epileptiform discharge (IED) detection based on convolutional neural network (CNN)
por: Zhang, Ling, et al.
Publicado: (2023)

A Prognostic Model of 15 Immune-Related Gene Pairs Associated With Tumor Mutation Burden for Hepatocellular Carcinoma
por: Huo, Junyu, et al.
Publicado: (2020)

Modeling nonsegmented negative-strand RNA virus (NNSV) transcription with ejective polymerase collisions and biased diffusion
por: Piedra, Felipe-Andrés, et al.
Publicado: (2023)

Emerging role of exosome-derived non-coding RNAs in tumor-associated angiogenesis of tumor microenvironment
por: Duan, Sai-Li, et al.
Publicado: (2023)

Proteomic Study of Aqueous Humor and Its Application in the Treatment of Neovascular Glaucoma
por: Yu, Mengxi, et al.
Publicado: (2020)

Prognostic Biomarker TP53 Mutations for Immune Checkpoint Blockade Therapy and Its Association With Tumor Microenvironment of Lung Adenocarcinoma
por: Lin, Xinqing, et al.
Publicado: (2020)

Construction of a ceRNA Network and Analysis of Tumor Immune Infiltration in Pancreatic Adenocarcinoma
por: Xiao, Jingjing, et al.
Publicado: (2021)

Identification and Validation of ATF3 Serving as a Potential Biomarker and Correlating With Pharmacotherapy Response and Immune Infiltration Characteristics in Rheumatoid Arthritis
por: Hu, Huan, et al.
Publicado: (2021)

Rare c-KIT c.1926delA and c.1936T>G Mutations in Exon 13 Define Imatinib Resistance in Gastrointestinal Stromal Tumors and Melanoma Patients: Case Reports and Cell Experiments
por: Yan, Chi, et al.
Publicado: (2022)

Identification of a Novel Tumor Microenvironment–Associated Eight-Gene Signature for Prognosis Prediction in Lung Adenocarcinoma
por: Ma, Chao, et al.
Publicado: (2020)

Identification of Tumor Mutation Burden, Microsatellite Instability, and Somatic Copy Number Alteration Derived Nine Gene Signatures to Predict Clinical Outcomes in STAD
por: Chen, Chuanzhi, et al.
Publicado: (2022)

Monitoring of breast cancer progression via aptamer-based detection of circulating tumor cells in clinical blood samples
por: Kolovskaya, Olga S., et al.
Publicado: (2023)

Tumor Microenvironment Characteristics of Pancreatic Cancer to Determine Prognosis and Immune-Related Gene Signatures
por: Zhang, Congjun, et al.
Publicado: (2021)

miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples
por: Detassis, Simone, et al.
Publicado: (2020)

The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice
por: Pogorelov, Vladimir M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7nuptahc4lgkhb0fv1tq1duto5