Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer

Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with breast cancer (BC) from healthy controls. Basing on high-throughput sequ...

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Autores principales: Wang, Jingyi, Ma, Ge, Ge, Han, Han, Xu, Mao, Xinrui, Wang, Xinyang, Veeramootoo, Jordee Selvamanee, Xia, Tiansong, Liu, Xiaoan, Wang, Shui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785726/
https://www.ncbi.nlm.nih.gov/pubmed/33402674
http://dx.doi.org/10.1038/s41523-020-00211-7
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author Wang, Jingyi
Ma, Ge
Ge, Han
Han, Xu
Mao, Xinrui
Wang, Xinyang
Veeramootoo, Jordee Selvamanee
Xia, Tiansong
Liu, Xiaoan
Wang, Shui
author_facet Wang, Jingyi
Ma, Ge
Ge, Han
Han, Xu
Mao, Xinrui
Wang, Xinyang
Veeramootoo, Jordee Selvamanee
Xia, Tiansong
Liu, Xiaoan
Wang, Shui
author_sort Wang, Jingyi
collection PubMed
description Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with breast cancer (BC) from healthy controls. Basing on high-throughput sequencing, 15 significantly upregulated tsRNAs were selected and assessed in cell supernatants and cell lines. 6 tsRNAs were identified and verified in a large cohort of 120 patients with BC and 112 healthy controls. tRF-Arg-CCT-017, tRF-Gly-CCC-001, and tiRNA-Phe-GAA-003 could serve as novel diagnostic biomarkers. Meanwhile, tRF-Arg-CCT-017 and tiRNA-Phe-GAA-003 could also act as prognostic biomarkers. Target genes of these tsRNAs were related to the development of cancers. These results suggested that specific tsRNAs in plasma might serve as diagnostic and prognostic biomarkers of BC.
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spelling pubmed-77857262021-01-14 Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer Wang, Jingyi Ma, Ge Ge, Han Han, Xu Mao, Xinrui Wang, Xinyang Veeramootoo, Jordee Selvamanee Xia, Tiansong Liu, Xiaoan Wang, Shui NPJ Breast Cancer Brief Communication Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with breast cancer (BC) from healthy controls. Basing on high-throughput sequencing, 15 significantly upregulated tsRNAs were selected and assessed in cell supernatants and cell lines. 6 tsRNAs were identified and verified in a large cohort of 120 patients with BC and 112 healthy controls. tRF-Arg-CCT-017, tRF-Gly-CCC-001, and tiRNA-Phe-GAA-003 could serve as novel diagnostic biomarkers. Meanwhile, tRF-Arg-CCT-017 and tiRNA-Phe-GAA-003 could also act as prognostic biomarkers. Target genes of these tsRNAs were related to the development of cancers. These results suggested that specific tsRNAs in plasma might serve as diagnostic and prognostic biomarkers of BC. Nature Publishing Group UK 2021-01-05 /pmc/articles/PMC7785726/ /pubmed/33402674 http://dx.doi.org/10.1038/s41523-020-00211-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Wang, Jingyi
Ma, Ge
Ge, Han
Han, Xu
Mao, Xinrui
Wang, Xinyang
Veeramootoo, Jordee Selvamanee
Xia, Tiansong
Liu, Xiaoan
Wang, Shui
Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_full Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_fullStr Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_full_unstemmed Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_short Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_sort circulating trna-derived small rnas (tsrnas) signature for the diagnosis and prognosis of breast cancer
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785726/
https://www.ncbi.nlm.nih.gov/pubmed/33402674
http://dx.doi.org/10.1038/s41523-020-00211-7
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