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Controllability over stressor decreases responses in key threat-related brain areas

Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability on responses to stressors is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how controllability altered responses to a shock-plus-sound st...

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Autores principales: Limbachia, Chirag, Morrow, Kelly, Khibovska, Anastasiia, Meyer, Christian, Padmala, Srikanth, Pessoa, Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785729/
https://www.ncbi.nlm.nih.gov/pubmed/33402686
http://dx.doi.org/10.1038/s42003-020-01537-5
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author Limbachia, Chirag
Morrow, Kelly
Khibovska, Anastasiia
Meyer, Christian
Padmala, Srikanth
Pessoa, Luiz
author_facet Limbachia, Chirag
Morrow, Kelly
Khibovska, Anastasiia
Meyer, Christian
Padmala, Srikanth
Pessoa, Luiz
author_sort Limbachia, Chirag
collection PubMed
description Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability on responses to stressors is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how controllability altered responses to a shock-plus-sound stressor with a between-group yoked design, where participants in controllable and uncontrollable groups experienced matched stressor exposure. Employing Bayesian multilevel analysis at the level of regions of interest and voxels in the insula, and standard voxelwise analysis, we found that controllability decreased stressor-related responses across threat-related regions, notably in the bed nucleus of the stria terminalis and anterior insula. Posterior cingulate cortex, posterior insula, and possibly medial frontal gyrus showed increased responses during control over stressor. Our findings support the idea that the aversiveness of stressors is reduced when controllable, leading to decreased responses across key regions involved in anxiety-related processing, even at the level of the extended amygdala.
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spelling pubmed-77857292021-01-14 Controllability over stressor decreases responses in key threat-related brain areas Limbachia, Chirag Morrow, Kelly Khibovska, Anastasiia Meyer, Christian Padmala, Srikanth Pessoa, Luiz Commun Biol Article Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability on responses to stressors is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how controllability altered responses to a shock-plus-sound stressor with a between-group yoked design, where participants in controllable and uncontrollable groups experienced matched stressor exposure. Employing Bayesian multilevel analysis at the level of regions of interest and voxels in the insula, and standard voxelwise analysis, we found that controllability decreased stressor-related responses across threat-related regions, notably in the bed nucleus of the stria terminalis and anterior insula. Posterior cingulate cortex, posterior insula, and possibly medial frontal gyrus showed increased responses during control over stressor. Our findings support the idea that the aversiveness of stressors is reduced when controllable, leading to decreased responses across key regions involved in anxiety-related processing, even at the level of the extended amygdala. Nature Publishing Group UK 2021-01-05 /pmc/articles/PMC7785729/ /pubmed/33402686 http://dx.doi.org/10.1038/s42003-020-01537-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Limbachia, Chirag
Morrow, Kelly
Khibovska, Anastasiia
Meyer, Christian
Padmala, Srikanth
Pessoa, Luiz
Controllability over stressor decreases responses in key threat-related brain areas
title Controllability over stressor decreases responses in key threat-related brain areas
title_full Controllability over stressor decreases responses in key threat-related brain areas
title_fullStr Controllability over stressor decreases responses in key threat-related brain areas
title_full_unstemmed Controllability over stressor decreases responses in key threat-related brain areas
title_short Controllability over stressor decreases responses in key threat-related brain areas
title_sort controllability over stressor decreases responses in key threat-related brain areas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785729/
https://www.ncbi.nlm.nih.gov/pubmed/33402686
http://dx.doi.org/10.1038/s42003-020-01537-5
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